Daily Archives: September 2, 2021
RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.
2 Sep, 2021 | 10:17h | UTCCommentaries:
Commentaries on Twitter
NEW—Baricitinib did not improve the composite primary endpoint of progression to NIV,
high-flow O2, IMV, or death; however, it did reduce 28-day all-cause mortality by 38·2% vs placebo (HR 0·57 [95% CI 0·41–0·78])Read the COV-BARRIER study: https://t.co/QrU6GW0XcQ#ISICEM2021
— The Lancet Respiratory Medicine (@LancetRespirMed) September 1, 2021
(thread – click for more)
1/?? NEW COVID THERAPY SAVES LIVES
Adding baricitinib to steroids will save 1,000s of hospitalized #COVID pts. Our @LancetRespirMed COV-Barrier study is FREE.
I explain?why it’s such a great #Pandemic discovery story: a new way to ⬇️ COVID19 deaths.https://t.co/8I5BlwyT2R pic.twitter.com/6KcfQrljqC
— WesElyMD (@WesElyMD) September 1, 2021
Review | COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.
2 Sep, 2021 | 10:06h | UTC
Commentary on Twitter
NEW REVIEW—COVID-19 and immune-mediated inflammatory diseases
Filippo Fagni and colleagues @UniFAU review the effect of disease and treatment on #COVID19 outcomes and #vaccine responseshttps://t.co/ue8XnDF1sM #LancetRheumatology @KorayTascilar pic.twitter.com/Yrk4SmeSbE
— The Lancet Rheumatology (@TheLancetRheum) August 27, 2021
Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.
2 Sep, 2021 | 10:10h | UTCCommentaries:
Long Covid in children ‘nowhere near scale feared’ – BBC
Related:
Cohort study: Risk factors for long covid in previously hospitalized children.
M-A: More than 50 long-term effects of COVID-19.
Commentary on Twitter (thread – click for more)
The worlds biggest study of post acute #COVID19 symptoms in children is out as a pre-print – the CLoCK study!
Fortunately results are very reassuring regarding symptom frequency and impact
Some important lessons, let's take a look ?
— Alasdair Munro (@apsmunro) September 1, 2021
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
2 Sep, 2021 | 10:05h | UTCWaning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv
Related:
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
Commentary on Twitter (thread – click for more)
The evidence of mRNA vaccine effectiveness (VE) waning grows: large Qatar experience shows substantial 5 month attrition for symptomatic infection VE below 50% and, to a lesser extent, vs hospitalization and deathhttps://t.co/4lIG68Bxm0 pic.twitter.com/rnyo0Si3RP
— Eric Topol (@EricTopol) August 27, 2021
Scientific Statement: Coronavirus Disease-2019 and Heart Failure.
2 Sep, 2021 | 10:08h | UTC
Commentary on Twitter
Released today: Coronavirus Disease-2019 and Heart Failure: A Scientific Statement from @HFSA, published in @JCardFail. @dranulala @ankeetbhatt @EricAdler17 @BhadeliaMD @AshishCorrea @ersied727 @heartofthemater @AndrewJSauer @NMHheartdoc @scottdsolomon https://t.co/fyWab32ruU pic.twitter.com/8pNY60I6gD
— HFSA (@HFSA) September 1, 2021
Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.
2 Sep, 2021 | 10:02h | UTCRelated:
We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.
WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19
CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk
RCT: Among critically ill patients, targeting oxygenation to a low-normal range vs. high-normal range did not result in a reduction in organ dysfunction.
2 Sep, 2021 | 08:23h | UTCEffect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA (free for a limited period)
Related:
M-A of randomized trials: Conservative oxygen therapy for critically ill patients.
Oxygen administration for patients with ARDS – Journal of Intensive Care
Commentary on Twitter
Multicenter RCT found, among critically ill patients, targeting oxygenation to a low-normal range compared with a high-normal range did not result in a statistically significant reduction in organ dysfunction https://t.co/lEq28bqmM4 #ISICEM21
— JAMA (@JAMA_current) August 31, 2021
EBM Learning | How to create PICO questions about diagnostic test. In this paper, the author presents an example of a PICO for a question about test accuracy and an example of a PICO for a question about the effects of care with a test.
2 Sep, 2021 | 08:18h | UTCHow to create PICO questions about diagnostic test – BMJ Evidence-Based Medicine
RCT: In patients with acute hypoxemic respiratory failure, a strategy of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal was not associated with improved outcomes.
2 Sep, 2021 | 08:21h | UTCEffect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial – JAMA (free for a limited period)
Related: Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS
Commentary on Twitter
In this randomized clinical trial that included 412 adults, 90-day mortality was 41.5% in the extracorporeal carbon dioxide removal group and 39.5% in the standard care group, a difference that was not statistically significant https://t.co/jhCY2r4qjX #ISICEM21
— JAMA (@JAMA_current) August 31, 2021
Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review - short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.
2 Sep, 2021 | 08:19h | UTCTreatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics
Expired cardiac devices may do global good, but safety unknown – A discussion of the ethics of using expired technology in parts of the world with no other options is long past due, some say.
2 Sep, 2021 | 08:16h | UTCExpired Cardiac Devices May Do Global Good, but Safety Unknown – TCTMD
Systematic review: In individuals with hemophilia A or B, there is evidence from RCTs that prophylaxis with clotting factor concentrates, as compared to on‐demand treatment, may reduce bleeding frequency.
2 Sep, 2021 | 08:17h | UTC
World leaders and experts call for significant reduction in the use of antimicrobial drugs in global food systems.
2 Sep, 2021 | 08:13h | UTCCommentary: Global group urges limits on antimicrobials in food production – CIDRAP
M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.
2 Sep, 2021 | 08:14h | UTC
Commentary on Twitter
The long, winding and expensive road leading to highly sensitive and specific noninvasive Dx of #NASH @Gut_BMJ https://t.co/ToIkF3yTAU
— Daniel J Drucker (@DanielJDrucker) May 25, 2021
RCT: Ketamine administration in patients with acute painful sickle cell crisis was effective for pain control and reduced the cumulative morphine dose in the emergency department.
2 Sep, 2021 | 08:11h | UTCKetamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)
M-A mostly of observational studies found that in patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infection Daptomycin was associated with a lower risk of clinical failure than Vancomycin, without differences in mortality.
2 Sep, 2021 | 08:10h | UTC