Daily Archives: August 22, 2021
Among patients receiving mRNA vaccines, clinically significant symptoms were more frequent following dose 2, following dose 1 in patients with previous SARS-CoV-2 infection, and in those who received the Moderna vaccine.
22 Aug, 2021 | 23:54h | UTC
Commentary on Twitter
New @JAMA_current paper says @moderna_Tx caused 2.3x the number of "significant" symptoms compared to @pfizer in a sample of 950 people.
Moderna also produced more antibodies. Raising the question of what a third dose, which produces still MORE, will do.https://t.co/drvhhsnpHo
— Alex Berenson (@AlexBerenson) August 16, 2021
[Preprint] Study shows symptomatic breakthrough infections are probably less transmissible than SARS-CoV-2 infections in unvaccinated individuals.
22 Aug, 2021 | 23:59h | UTC
Commentary on Twitter (thread – click for more)
Did you hear vaccinated people with Delta “have just as much virus in their nose so are just as infectious as unvaccinated”?
Turns out vaccinated people have significantly less culturable virus present at the same Ct count
They are LESS INFECTIOUS ? https://t.co/OX0Ul0ntWc pic.twitter.com/3vDQSJ6j84
— Alasdair Munro (@apsmunro) August 22, 2021
Evidence mounts that people with breakthrough infections can spread Delta easily.
22 Aug, 2021 | 23:57h | UTCOriginal study: Shedding of Infectious SARS-CoV-2 Despite Vaccination when the Delta Variant is Prevalent – Wisconsin, July 2021 – medRxiv
Commentary on Twitter
The evidence that supports Delta breakthrough infections ability to spread (and why fully vaccinated people need to ? up)https://t.co/27NOf6mYCM @NatGeo by @Ecquis w/ studies and input by @GuptaR_lab and @KasenRiemersma
— Eric Topol (@EricTopol) August 20, 2021
Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.
22 Aug, 2021 | 23:51h | UTCInvited Commentary: Heterologous ChAdOx1-nCoV19–BNT162b2 vaccination provides superior immunogenicity against COVID-19
Related:
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)
Commentary on Twitter
NEW Research—Heterologous ChAdOx1 nCov-19–BNT162b2 immunisation w/ 10–12-week interval is well tolerated & improves immunogenicity vs homologous ChAdOx1 nCov-19 vax w/ 10–12-week interval & BNT162b2 vax w/ 3-week interval
Study from Prof Sander & co https://t.co/VAB54NokSi pic.twitter.com/wfeBsvoKhO
— The Lancet Respiratory Medicine (@LancetRespirMed) August 13, 2021
Study Commentaries: Non-invasive ventilation for COVID 19 patients. The Recovery RS trial.
22 Aug, 2021 | 23:52h | UTCCommentary 1: JC: Non-invasive ventilation for COVID 19 patients. The Recovery RS trial – St Emlyn’s
CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil – Effectiveness against symptomatic disease was 46.8%, 55.5% against hospitalization, and 61.2% against deaths.
22 Aug, 2021 | 23:48h | UTCEditorial: Real world effectiveness of covid-19 vaccines
Related: CoronaVac vaccine: its results are patchy, but the world can’t ignore its usefulness. (several texts on the subject)
[Preprint] SARS-CoV-2 aerosol transmission in schools: theoretical effectiveness of different interventions – “Combined interventions (i.e., natural ventilation, masks, and HEPA filtration) were the most effective (≥ 30-fold decrease)”.
22 Aug, 2021 | 23:50h | UTCSARS-CoV-2 aerosol transmission in schools: the effectiveness of different interventions – medRxiv
Related: The right way to protect our children and return to in-person learning – CNN
Commentaries on Twitter
Interesting modelling study for schools: (theoretically) most effective is open windows, then masks, then HEPA filter. Would be good to do real world tests though. https://t.co/MDFNqNNUI3 pic.twitter.com/xGSodClipO
— Paul Glasziou (@PaulGlasziou) August 21, 2021
This is not real evidence supporting real policy choices as they are really carried out in the real world.
Instead, this is theoretical bioplausibility spun into a full paper.
I hope folks can still tell the two aparthttps://t.co/znwtiaKZ2g
— Vinay Prasad, MD MPH ?️? (@VPrasadMDMPH) August 20, 2021
The Lancet Series: Heat and health.
22 Aug, 2021 | 23:04h | UTCHomepage: Heat and health
Editorial: Health in a world of extreme heat
Ollie Jay: managing heat, improving health
Hot weather and heat extremes: health risks
Observational data from Canada: Effectiveness of mRNA covid-19 vaccines was 91% against symptomatic disease and 98% against hospitalization and deaths.
22 Aug, 2021 | 23:47h | UTCEditorial: Real world effectiveness of covid-19 vaccines
ACOG Guideline: Osteoporosis prevention, screening, and diagnosis.
22 Aug, 2021 | 23:08h | UTC
NICE Guideline: Obstructive sleep apnea/hypopnea syndrome and obesity hypoventilation syndrome in over 16s.
22 Aug, 2021 | 23:10h | UTC
M-A: GLP-1 receptor agonists reduce major adverse cardiovascular events, all-cause mortality, hospital admission for heart failure, and worsening kidney function in patients with type 2 diabetes.
22 Aug, 2021 | 22:50h | UTCCardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Hot, Cold, and Deadly – Extreme temperature is a threat to global health.
22 Aug, 2021 | 23:01h | UTCHot, Cold, and Deadly – Think Global Health
Estimating the cause-specific relative risks of non-optimal temperature on daily mortality: a two-part modeling approach applied to the Global Burden of Disease Study.
22 Aug, 2021 | 23:02h | UTCRelated article: Mortality risk attributable to high and low ambient temperature: a multicountry observational study – The Lancet
Commentary on Twitter
? This #GBDstudy new in @TheLancet in is the first comprehensive global assessment of disease burden due to non-optimal temperature exposure. #ClimateChange #Research #GlobalHealth https://t.co/AUqTFHkTZL
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) August 20, 2021
M-A: The role of SGLT2 inhibitors in heart failure.
22 Aug, 2021 | 22:46h | UTCRelated:
ESC Position Paper: Cardiac, renal, and metabolic effects of SGLT2 inhibitors.
Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.
Why remote consultation with a doctor is difficult – and how it can be improved.
22 Aug, 2021 | 23:00h | UTCWhy remote consultation with a doctor is difficult – and how it can be improved – The Conversation
Original article: Planning and Evaluating Remote Consultation Services: A New Conceptual Framework Incorporating Complexity and Practical Ethics – Frontiers in Digital Health
Commentary on Twitter
My new piece for @ConversationUK on why setting up doctor-in-your-pocket video consultation services for the young and healthy is as easy as putting up a lemonade stall – but making remote consulting work for a wider demographic is much more challenging. https://t.co/SQZHozFTtg
— Trisha Greenhalgh (@trishgreenhalgh) August 20, 2021
Health researchers report funder pressure to suppress results – “Small study hints that interference from bodies funding research into public-health issues such as nutrition and exercise might be more common than realized”.
22 Aug, 2021 | 22:41h | UTCHealth researchers report funder pressure to suppress results – Nature
Original study: “He who pays the piper calls the tune”: Researcher experiences of funder suppression of health behaviour intervention trial findings – PLOS One
The assessment of blood pressure in pregnant women: pitfalls and novel approaches.
22 Aug, 2021 | 22:12h | UTC
Commentary on Twitter
AJOG Expert Review in Preeclampsia: The assessment of blood pressure in pregnant women: pitfalls and novel approaches https://t.co/6GBAtZuv5U pic.twitter.com/joayfaqKUK
— AJOG (@AJOG_thegray) August 22, 2021
Survey: Workplace mistreatment reported frequently by emergency medicine residents.
22 Aug, 2021 | 22:18h | UTCWorkplace Mistreatment Reported Frequently by Emergency Medicine Residents – HealthDay
Original study: Prevalence of Discrimination, Abuse, and Harassment in Emergency Medicine Residency Training in the US – JAMA Network Open
Commentary on Twitter
In this study, 45.1% of emergency medicine residents reported exposure to workplace mistreatment. Interventions should be developed to ensure resident wellness and career satisfaction. @ABEMCert @EmoryMedicine @NUFeinbergMed @Rutgers_NJMS @UWMedicine https://t.co/dTrUH14NxB
— JAMA Network Open (@JAMANetworkOpen) August 20, 2021
Study: Macrolide use significantly associated with both prevalent and incident tinnitus.
22 Aug, 2021 | 22:11h | UTCCommentary: Macrolide Use and Tinnitus: A New Safety Ringtone? – NEJM Journal Watch (free for a limited period)
Viewpoint: Sentinel lymph node biopsy in cutaneous melanoma—where do we stand?
22 Aug, 2021 | 22:16h | UTCSentinel Lymph Node Biopsy in Cutaneous Melanoma—Where Do We Stand? – JAMA Dermatology (free for a limited period)
Treatment escalation vs. immediate initiation of highly effective treatment for patients with relapsing-remitting multiple sclerosis: data from 2 different national strategies.
22 Aug, 2021 | 22:06h | UTCTreatment Escalation vs Immediate Initiation of Highly Effective Treatment for Patients With Relapsing-Remitting Multiple Sclerosis: Data From 2 Different National Strategies – JAMA Neurology (free for a limited period)
Commentary on Twitter
Study suggests that escalation of #multiplesclerosis treatment was inferior to initial treatment with a more effective disease-modifying agent https://t.co/hkHsAXP5se
— JAMA Neurology (@JAMANeuro) August 16, 2021