Daily Archives: August 20, 2021
[Preprint] Pfizer vaccine effectiveness against Delta declines faster than AstraZeneca, both offering the same protection after 4 months.
20 Aug, 2021 | 10:03h | UTCCommentaries:
Pfizer vaccine effectiveness declines faster than AstraZeneca – study – Evening Standard
Commentary on Twitter
New large UK study confirms attrition of @Pfizer vaccine effectiveness vs Delta infections over time https://t.co/K6YRyAQq4o "By roughly 4 1/2 months after the 2nd dose, Pfizer’s shot will probably be about on par with Astra’s at preventing infections with a high viral burden" pic.twitter.com/x1Nl2BkWfn
— Eric Topol (@EricTopol) August 19, 2021
Covid-19: How many variants are there, and what do we know about them?
20 Aug, 2021 | 10:00h | UTCCovid-19: How many variants are there, and what do we know about them? – The BMJ
Commentary on Twitter
Eight notable variants of SARS-CoV-2 have been found since September 2020. @emahase_ reviews the line-up so far https://t.co/jmzfnbudoL
Watch this video showing how the variants have spread around the globe: pic.twitter.com/KwBl6B48Dy
— The BMJ (@bmj_latest) August 19, 2021
New SARS-CoV-2 variants have changed the pandemic. What will the virus do next?
20 Aug, 2021 | 09:58h | UTCNew SARS-CoV-2 variants have changed the pandemic. What will the virus do next? – Science
Commentary on Twitter
I really, really wish Covid deniers and minimizers would read this outstanding @ScienceMagazine piece by @kakape on the delta variant and how it has completely changed this pandemic – FOR THE WORSEhttps://t.co/liIC9NpGOJ pic.twitter.com/UkCieUUCpK
— Madhu Pai, MD, PhD (@paimadhu) August 19, 2021
The Origins of SARS-CoV-2: A Critical Review.
20 Aug, 2021 | 09:52h | UTCThe Origins of SARS-CoV-2: A Critical Review – Cell
Related:
Fauci says natural origins theory of coronavirus is still the most likely.
A grim warning from Israel: Vaccination blunts, but does not defeat Delta.
20 Aug, 2021 | 09:56h | UTCA grim warning from Israel: Vaccination blunts, but does not defeat Delta – Science
Delta’s rise is fuelled by rampant spread from people who feel fine.
20 Aug, 2021 | 09:54h | UTCDelta’s rise is fuelled by rampant spread from people who feel fine – Nature
Original study: Transmission dynamics and epidemiological characteristics of Delta variant infections in China – medRxiv
Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.
20 Aug, 2021 | 09:51h | UTC
Commentary on Twitter
Post-COVID19 tachycardia syndrome(s): nice proposal for phenotypeshttps://t.co/XI75HCGYUH pic.twitter.com/yg303QXd1E
— Otavio Ranzani (@otavio_ranzani) August 18, 2021
Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team.
20 Aug, 2021 | 09:49h | UTC
Spontaneous Coronary Artery Dissection: Pitfalls of Angiographic Diagnosis and an Approach to Ambiguous Cases.
20 Aug, 2021 | 09:06h | UTCCommentary and summary: Spontaneous Coronary Artery Dissection Diagnosis – American College of Cardiology
M-A of randomized trials: The effect of higher versus lower protein delivery in critically ill patients – “In critically ill patients, a higher daily protein delivery was not associated with any improvement in clinical or patient-centered outcomes”.
20 Aug, 2021 | 08:57h | UTC
M-A: Examination of dosing of antipsychotic drugs for relapse prevention in patients with stable schizophrenia.
20 Aug, 2021 | 09:04h | UTCExamination of Dosing of Antipsychotic Drugs for Relapse Prevention in Patients With Stable Schizophrenia: A Meta-analysis – JAMA Psychiatry (free for a limited period)
Commentaries on Twitter
Crucial literature review on optimal antipsychotic dosing for long term maintenance in #Schizophrenia.
Conclusion: Seek Goldilocks "just right"- definitely not high because of bad side effects, but not so low as to risk relapse.
Often easier said than done. https://t.co/RBBPBMzn9D
— Allen Frances (@AllenFrancesMD) August 20, 2021
Doses higher than 5mg/day risperidone equivalent are not more effective for relapse prevention than lower doses in #schizophrenia. But caution is required at the lower end of the dose-response curve where relapse risk disproportionally increases https://t.co/kQcnuRtzYU
— JAMA Psychiatry (@JAMAPsych) August 19, 2021
Heart, mind, and soul: spirituality in cardiovascular medicine.
20 Aug, 2021 | 09:06h | UTCHeart, mind, and soul: spirituality in cardiovascular medicine – European Heart Journal
Commentary on Twitter
Have you ever thought about the impact of spirituality on cardiovascular outcomes? You’d better meditate….https://t.co/hhf4vRoLxX#cardiotwitter @ESC_Journals @escardio pic.twitter.com/GP8cdZfTP5
— EHJ Editor-in-Chief (@ehj_ed) August 19, 2021
Prescription medications for use in pregnancy – perspective from the US Food and Drug Administration.
20 Aug, 2021 | 08:55h | UTC
Commentary on Twitter
"There are only 9 [NINE!] drugs that have ever been approved and marketed in the United States for obstetrical indications."
Pregnant individuals deserve data to help them make informed decisions. #ResearchPregnancy https://t.co/sj7dWUzKNZ
— All Source Pregnancy (@PregnancyAll) July 17, 2021
M-A: Prevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation.
20 Aug, 2021 | 09:01h | UTCPrevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation: a systematic review and meta-analysis of 4,200,000 patients – European Heart Journal (link to abstract – $ for full-text)
Commentary on Twitter
AF-COMET Meta-analysis showed #COPD is common in #AF, being found in 13% of patients
?⬆️ burden of comorbidities & worse outcomes
?More than a two-fold ⬆️ risk of all-cause death
?⬆️ Risk of CV death and major bleedinghttps://t.co/fLAuGkQAX1 @ESC_Journals @SchakrabartiEP pic.twitter.com/50OSfACH84— Henry Han, MBBS, MD (@HanCardiomd) August 2, 2021
Health care for people who are incarcerated.
20 Aug, 2021 | 08:46h | UTCHealth care for people who are incarcerated – Nature Reviews Diseases Primers
Commentary on Twitter
This Comment highlights the high medical burden of individuals who are or have been in #prison or jail and discusses how to overcome barriers to #HealthCare through funding, community health systems and addressing stigma and discrimination.https://t.co/w0z0iGIKS5 pic.twitter.com/wRuAgCZ6i7
— Nature Reviews Disease Primers (@DiseasePrimers) August 19, 2021
Variations in end-of-life practices in intensive care units worldwide: a prospective observational study.
20 Aug, 2021 | 08:51h | UTCVariations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Limitation of life-sustaining therapies is common worldwide with regional variability. Withholding treatment is more common than withdrawing treatment. Variations in type, frequency, and timing of end-of-life decisions were observed. https://t.co/skfjazyt7x @LancetRespirMed
— Martijn A. Spruit (@pulmonary_rehab) August 9, 2021
Study finds increased risk of gastrointestinal bleeding following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants.
20 Aug, 2021 | 08:45h | UTCGastrointestinal bleeding risk following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants – Heart (link to abstract – $ for full-text)
Commentary on Twitter
In this @Heart_BMJ #Afib sdy @AndersHolt6 et al. found a X2 ⬆️ risk of GI bleeding w/ NOAC?+oral glucocorticoids⚪ vs NOAC alone ?
Authors recommend ☝️ close monitoring ? or other risk ? mitigation when co-prescribing
? https://t.co/CgtgmvnD29#CardioTwitter #cardiology pic.twitter.com/95eCOWxozK
— Copenhagen Cardiovascular Research Center (@CopCard) August 15, 2021
Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection.
20 Aug, 2021 | 08:41h | UTC
Dementia at younger ages is more prevalent than previously estimated, meta-analysis suggests.
20 Aug, 2021 | 08:53h | UTCOriginal study: Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
Review: Viral respiratory pathogens and lung injury.
20 Aug, 2021 | 08:43h | UTCViral Respiratory Pathogens and Lung Injury – Clinical Microbiology Reviews
Metrics for evaluating antibiotic use and prescribing in outpatient settings.
20 Aug, 2021 | 08:40h | UTC
Cohort study: Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers.
20 Aug, 2021 | 08:39h | UTC
Commentary on Twitter
For #BRCA1 mutation carriers, longer duration of oral contraceptive use (>10 yr) is associated with a greater reduction in #OvarianCancer risk, and the protection is long term. https://t.co/HrrutgaYKX
— Anna Chichura, MD (@AnnaChichuraMD) July 3, 2021