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Daily Archives: July 27, 2021

Review: Long covid—mechanisms, risk factors, and management.

27 Jul, 2021 | 03:52h | UTC

Long covid—mechanisms, risk factors, and management – The BMJ

 

Commentary on Twitter

 

Major medical groups call for employers to mandate Covid-19 vaccines for health care workers.

27 Jul, 2021 | 03:44h | UTC

Major medical groups call for employers to mandate Covid-19 vaccines for health care workers – CNN

Original Document: Joint Statement in Support of COVID-19 Vaccine Mandates for All Workers in Health and Long-Term Care

 

Commentaries on Twitter

 

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

27 Jul, 2021 | 03:48h | UTC

Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination – Nature Medicine

Commentary: A ‘mix and match’ approach to SARS-CoV-2 vaccination – Nature Medicine

Related:

WHO warns against mixing and matching COVID vaccines.

Germany issues world’s strongest recommendation for mixing Covid-19 vaccines.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

 

Commentary on Twitter

 

[Preprint] Covid-19: Longer interval between Covid-19 Pfizer vaccine doses boosts immunity.

27 Jul, 2021 | 03:50h | UTC

News release: Longer interval between Covid-19 Pfizer vaccine doses boosts immunity – Newcastle University

Original Study (preprint): Sustained T cell immunity, protection and boosting using extended dosing intervals of BNT162b2 mRNA vaccine

Commentaries:

Commentary: Covid-19: Longer interval between Pfizer doses results in higher antibody levels, research finds – BMJ

Expert reaction to preprint from PITCH study looking at interval between two Pfizer vaccine doses, and antibody and T-cell responses – Science Media Centre

Related:

Debate: Should we delay second vaccine doses to give one dose of the Covid-19 vaccine to more people? (several texts on the subject)

 

Safety evaluation of the second dose of mRNA COVID-19 vaccines in patients with immediate reactions to the first dose.

27 Jul, 2021 | 03:42h | UTC

Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose – JAMA Internal Medicine

Commentaries:

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose – Massachusetts General Hospital

No anaphylaxis after second dose of mRNA COVID vaccine, study finds – CIDRAP

 

Commentary on Twitter

 

Opinion | What does public health really mean? Lessons from covid-19.

27 Jul, 2021 | 03:46h | UTC

What does public health really mean? Lessons from covid-19 – The BMJ Opinion

 

Commentary on Twitter (thread – click for more)

 

Using Updated PubMed: New features and functions to enhance literature searches.

27 Jul, 2021 | 03:32h | UTC

Using Updated PubMed: New Features and Functions to Enhance Literature Searches – JAMA (free for a limited period)

 

[Preprint] Test-negative case-control study: Effectiveness of Oxford-AstraZeneca vaccine in older people during SARS-CoV-2 Gamma variant transmission in Brazil – Adjusted effectiveness was 77.9% for symptomatic Covid-19, 87.6% against hospitalization, and 93.6% against death.

27 Jul, 2021 | 03:41h | UTC

Effectiveness of the ChAdOx1 vaccine in the elderly during SARS-CoV-2 Gamma variant transmission in Brazil – medRxiv

 

Commentary on Twitter (thread – click for more)

 

[Preprint] Test-negative case-control study: Effectiveness of CoronaVac vaccine in older people during SARS-CoV-2 Gamma variant transmission in Brazil – Adjusted vaccine effectiveness was 41.6% for symptomatic Covid-19, 59.0% against hospitalizations and 71.4% against deaths.

27 Jul, 2021 | 03:39h | UTC

Effectiveness of the CoronaVac vaccine in the elderly population during a Gamma variant-associated epidemic of COVID-19 in Brazil: A test-negative case-control study – medRxiv

 

Commentary on Twitter (thread – click for more)

 

NICE Guideline | Clostridioides difficile infection: antimicrobial prescribing.

27 Jul, 2021 | 03:34h | UTC

Clostridioides difficile infection: antimicrobial prescribing – National Institute for Health and Care Excellence

Infographic: Clostridioides difficile infection: antimicrobial prescribing

Related:

IDSA 2021 focused update guidelines on the management of Clostridioides difficile infection in adults.

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections.

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases

Review | My Treatment Approach to Clostridioides difficile Infection.

 

CoronaVac vaccine: its results are patchy, but the world can’t ignore its usefulness.

27 Jul, 2021 | 03:38h | UTC

CoronaVac vaccine: its results are patchy, but the world can’t ignore its usefulness – The Conversation

Related:

RCT: CoronaVac showed efficacy of 83.5% for preventing symptomatic SARS-CoV-2 infection.

Prospective national cohort in Chile showed CoronaVac effectiveness was 65.9% for symptomatic Covid-19, 87.5% for hospitalization, 90.3% for ICU admission, and 86.3% for death.

Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.

Perspective | Are Chinese COVID vaccines underperforming? a dearth of real-life studies leaves unanswered questions.

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic.

Brazilian town experiment shows mass vaccination can wipe out COVID-19.

WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.

[Press release – not published yet] The city of Serrana in Brazil has seen a 95% drop in Covid-19 deaths after almost all adults were vaccinated with Chinese CoronaVac – The findings suggest the pandemic can be controlled after 75% of people are fully vaccinated.

[Not published yet] Observational study in Uruguay found CoronaVac reduced mortality by 97 percent – “In people who had received two doses, it reduced infection with the coronavirus by 57 percent and intensive care admissions by 95 percent”.

 

Review: A pathophysiological compass to personalize antianginal drug treatment.

27 Jul, 2021 | 03:27h | UTC

A pathophysiological compass to personalize antianginal drug treatment – Nature Reviews Cardiology (free for a limited period)

 

Commentary on Twitter

 

Systematic review: Compression bandages or stockings vs. no compression for treating venous leg ulcers.

27 Jul, 2021 | 03:31h | UTC

Compression bandages or stockings versus no compression for treating venous leg ulcers – Cochrane Library

Summary: Compression bandages or stockings versus no compression for treating venous leg ulcers – Cochrane Library

 

Cluster RCT: Effectiveness of a tailored intervention to reduce antibiotics for urinary tract infections in nursing home residents.

27 Jul, 2021 | 03:25h | UTC

Effectiveness of a tailored intervention to reduce antibiotics for urinary tract infections in nursing home residents: a cluster, randomised controlled trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Research provides vital insights about excess coffee consumption and brain health.

27 Jul, 2021 | 03:28h | UTC

Commentary: Research provides vital insights about excess coffee consumption and brain health – University of South Australia/ News Medical

Original study: High coffee consumption, brain volume and risk of dementia and stroke – Nutritional Neuroscience (link to abstract – $ for full-text)

 

Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence.

27 Jul, 2021 | 03:23h | UTC

Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence – Journal of Clinical Epidemiology

 

Review: Insulin therapy for the non-specialist physician.

27 Jul, 2021 | 03:18h | UTC

Insulin therapy for the non-specialist physician – Clinical Medicine Journal

 

Review: Diabetes and the kidney.

27 Jul, 2021 | 03:16h | UTC

Diabetes and the kidney – Clinical Medicine Journal

 

AHA Report: Recommendations for statistical reporting in cardiovascular medicine.

27 Jul, 2021 | 03:22h | UTC

Recommendations for Statistical Reporting in Cardiovascular Medicine: A Special Report From the American Heart Association – Circulation

 

Commentary on Twitter (thread – click for more)

 

Review: Managing hyperglycemia in inpatients.

27 Jul, 2021 | 03:21h | UTC

Managing hyperglycaemia in inpatients – Clinical Medicine Journal

 

Review: Uncommon forms of diabetes.

27 Jul, 2021 | 03:14h | UTC

Uncommon forms of diabetes – Clinical Medicine Journal

 

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