Daily Archives: July 13, 2021
German national treatment guidance for hospitalized COVID-19 patients.
13 Jul, 2021 | 10:02h | UTC
Long Covid: 39% of patients report persistent symptoms more than seven months after diagnosis of COVID-19 in an outpatient setting.
13 Jul, 2021 | 09:57h | UTCCommentaries: Long COVID symptoms in a third of people with COVID-19 – American College of Physicians AND Covid-19: 1-in-3 Patients Reported Long-Hauler Symptoms – Physician’s Weekly
Commentary on Twitter
A new prospective cohort study of >400 people with mild to moderate (outpatient) covid at 7-9 months: nearly 1 of 3 had persistent symptoms #LongCovid @AnnalsofIM
https://t.co/ix1Hhsm0iZ
by @mayssamnehme and colleagues pic.twitter.com/Uc4UEclDvA— Eric Topol (@EricTopol) July 5, 2021
WHO warns against mixing and matching COVID vaccines.
13 Jul, 2021 | 09:53h | UTCWHO warns against mixing and matching COVID vaccines – Reuters
Commentary: WHO cautions data still limited on mixing COVID-19 vaccines, but Canadian officials say it’s OK – CTV News
Related: Germany issues world’s strongest recommendation for mixing Covid-19 vaccines. AND [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Perspective | Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects. AND Should you mix and match COVID-19 vaccines? Scientists are seeking answers
Commentary on Twitter
The World Health Organization's chief scientist on Monday advised against people mixing and matching COVID-19 vaccines from different manufacturers, calling it a "dangerous trend" since there was little data available about the health impact. https://t.co/Oog6fWDSMz
— Reuters Health (@Reuters_Health) July 13, 2021
Large genomic analysis has identified 13 new genomic regions associated with susceptibility and severity to Covid-19.
13 Jul, 2021 | 09:59h | UTCMapping the human genetic architecture of COVID-19 – Nature
Commentaries: The quest to find genes that drive severe COVID – Nature AND Gene hunters turn up new clues to help explain why Covid-19 hits some people so hard – STAT AND Large genomic analysis highlights COVID-19 risk factors – Broad Institute of MIT and Harvard AND A new study finds genetic variations in Covid patients that could point to better drug treatments. – The New York Times AND How your DNA may affect whether you get COVID-19 or become gravely ill – ScienceNews
[Preprint] Long Covid: Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people.
13 Jul, 2021 | 09:55h | UTCCommentary: Study explores the prevalence of long COVID in England – News Medical
Extremely rare cases of Guillain-Barré reported with Johnson & Johnson vaccine for Covid-19.
13 Jul, 2021 | 09:48h | UTCJ&J’s Covid-19 vaccine may trigger neurological condition in rare cases, FDA says – STAT
See also: Johnson & Johnson Vaccine Is Linked To Neurological Disorder In Extremely Rare Cases – NPR AND F.D.A. Attaches Warning of Rare Nerve Syndrome to Johnson & Johnson Vaccine – The New York Times
Pro-Con Debate | Should we delay covid-19 vaccination in children?
13 Jul, 2021 | 09:51h | UTCShould we delay covid-19 vaccination in children? – The BMJ
News release: Should we delay COVID-19 vaccination in children? – British Medical Journal
Commentary on Twitter
Covid-19 vaccines in adults have been remarkably effective. There is good reason to expect that the same will be true in children.
A group of authors discuss the pros and cons of vaccinating children against covid-19 https://t.co/TOEI67YPeH
— The BMJ (@bmj_latest) July 9, 2021
WHO issues new recommendations on human genome editing for the advancement of public health.
13 Jul, 2021 | 09:42h | UTCSee reports:
Human genome editing: recommendations
Human genome editing: a framework for governance
Commentaries: New Global Recommendations for Human Genome Editing may Improve Use to Cure and Treat Diseases – Health Policy Watch AND WHO should lead on genome-editing policy, advisers say – Nature AND WHO Calls for Global Registry of Human Genome Editing – HealthDay AND Expert reaction to the WHO’s newly published recommendations and governance framework for human genome editing – Science Media Centre
Commentary on Twitter (thread – click for more)
Two ? reports provide the first global recommendations to help establish human genome ? editing as a tool for public health, with an emphasis on safety, effectiveness and ethics.
? https://t.co/w32QhMXSXi pic.twitter.com/Bto9SF6NzW
— World Health Organization (WHO) (@WHO) July 12, 2021
Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.
13 Jul, 2021 | 09:33h | UTCA Randomized Clinical Trial Evaluating the Efficacy and Quality of Life of Antibiotic-only Treatment of Acute Uncomplicated Appendicitis: Results of the COMMA Trial – Annals of Surgery (link to abstract – $ for full-text)
Related: A Randomized trial comparing antibiotics with appendectomy for appendicitis AND Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin AND Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis AND Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis AND Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children AND Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International
Commentary on Twitter
The debate continues!
Another RCT comparing antibiotics to surgery for uncomplicated appendicitis – COMMA trial from ??
Recurrence within 1-year : 25% after AB
Superior quality of life at 3 and 12mo after surgery.https://t.co/Yv51qpxchb
— Ville Sallinen (@villesallinen) July 11, 2021
2021 ACR Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.
13 Jul, 2021 | 09:41h | UTC
Podcast | An Antibiotics Primer.
13 Jul, 2021 | 09:35h | UTC#284 An Antibiotics Primer, with @IDdocAdi – The Curbsiders
WHO criticizes rich countries for planning COVID vaccine ‘boosters’ – while billions wait for first jab.
13 Jul, 2021 | 09:45h | UTCCOVID-19 booster strategy as Delta multiplies, highlights ‘disappointing inequality’: WHO – UN News
See also: WHO Lambasts Pfizer, Moderna & Rich Countries for Planning COVID Vaccine ‘Boosters’ – While Billions Wait for First Jab – Health Policy Watch AND WHO says vaccinated countries must stop ordering booster shots until others are fully vaccinated – ABC News
2021 ACR Guideline for the Management of Polyarteritis Nodosa.
13 Jul, 2021 | 09:37h | UTC
M-A: Similar mortality with Fluoroquinolones or Macrolides for the treatment of Legionella Pneumonia.
13 Jul, 2021 | 09:18h | UTCAre Fluoroquinolones or Macrolides Better for Treating Legionella Pneumonia? A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)
Review: Infectious disease-associated encephalopathies.
13 Jul, 2021 | 09:30h | UTCInfectious disease-associated encephalopathies – Critical Care
Commentary on Twitter
A Review published in Critical Care focuses on the pathophysiology of encephalopathies associated with sepsis, malaria, influenza, and COVID-19; emerging therapeutic strategies; and the role of neuroinflammation. https://t.co/991S4kAKJk
— BMC (@BioMedCentral) July 11, 2021
Top 10 pearls for the recognition, evaluation, and management of maternal sepsis.
13 Jul, 2021 | 09:25h | UTC
M-A: Global prevalence of functional constipation according to the Rome criteria.
13 Jul, 2021 | 09:17h | UTC
Commentary on Twitter
New research – Barberio et al – Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysishttps://t.co/pqkXltWnYU#constipation #gitwitter @bribarberio @DrCJudge @EdoardoSavarino @alex_ford12399 pic.twitter.com/NUnZgaVS46
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) June 4, 2021
RCT: Comparison of nebulized ketamine at three different dosing regimens for treating painful conditions in the emergency department.
13 Jul, 2021 | 09:22h | UTCComparison of Nebulized Ketamine at Three Different Dosing Regimens for Treating Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind Clinical Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Nebulized Ketamine for pain in the ED? No way…Well- here you go-Comparison of Nebulized Ketamine at Three Different Dosing Regimens for Treating Painful Conditions in the ED. https://t.co/v3UT0Y0LdU #FOAMed #FOAMems #FOAMtox #FOAMcc #FOAMpharm
— Sergey Motov (@painfreeED) July 3, 2021
RCT: Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma.
13 Jul, 2021 | 09:20h | UTC
Commentary on Twitter
Long-term outcomes from the NEOCRTEC5010 demonstrated the survival benefit of neoadjuvant chemoradiotherapy followed by surgery compared with surgery alone for patients with locally advanced esophageal squamous cell carcinoma https://t.co/UBBEEAynsy
— JAMA Surgery (@JAMASurgery) June 29, 2021
Monitoring blood pressure at home: guidance for Canadian patients.
13 Jul, 2021 | 09:15h | UTC