Daily Archives: June 8, 2021 | LinksMedicus Free Medical News & Perspectives

Short review: Neurological complications of COVID-19.

8 Jun, 2021 | 09:36h | UTC

Neurological complications of COVID-19 – Intensive Care Medicine

Commentary on Twitter

NeuroCOVID potential mechanism(s)?
? #COVID19 neuro-complications
? direct neuroinvasion
? inflammatory/autoimmune
? vascular
+
? #ICU complications
? drugs toxicity/side effects
? PICS/PACS & PTSD
Challenging to identify/diagnose: strictly monitor! https://t.co/0YlAoanUFo pic.twitter.com/unM0SWFR7L

— Intens Care Med (@yourICM) June 7, 2021

Underlying medical conditions associated with severe COVID-19 illness among children – the strongest risk factors for hospitalization were chronic and complex chronic diseases, type 1 diabetes, and obesity.

8 Jun, 2021 | 09:37h | UTC

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children – JAMA Network Open

Commentaries: Underlying illness, respiratory infection raise risk for severe COVID in kids – CIDRAP AND COVID-19 in Children—Not Just Little Adults – JAMA Network Open

Commentary on Twitter

This cross-sectional study found a higher risk of severe #COVID19 illness among children with medical complexity and certain underlying conditions, such as type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity. https://t.co/ifq1Ao0HKS

— JAMA Network Open (@JAMANetworkOpen) June 7, 2021

Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

8 Jun, 2021 | 09:29h | UTC

Are SARS-CoV-2 Human Challenge Trials Ethical? – JAMA Internal Medicine

Related: World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject)

Commentary on Twitter

I am not convinced of #SARSCoV2 #ChallengeTrials. You should not pay volunteers. If things go wrong, there is no effective treatment. What will be learnt from mild disease, when you are interested in severe disease? #COVID19 #Covid #Corona #coronavirus https://t.co/JjXDJDfOl2

— Martin Michaelis (@MartMichaelis) June 8, 2021

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

8 Jun, 2021 | 09:34h | UTC

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – Annals of Internal Medicine

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

8 Jun, 2021 | 09:33h | UTC

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – CDC Emerging Infectious Diseases

Commentary: COVID19: Secondary Infections Still a Big Challenge in India – News Click

Commentary on Twitter

New study from India on mucormycosis

– COVID-19 has led to increases in mucormycosis, partly from inappropriate steroid use

– Uncontrolled diabetes was the most common underlying disease

Better diabetes care & rational steroid use are key!https://t.co/Wv8kCyTDtK pic.twitter.com/KK78BKg2Xf

— Madhu Pai, MD, PhD (@paimadhu) June 7, 2021

Report: 376,000 people in UK have had long Covid symptoms for at least a year.

8 Jun, 2021 | 09:27h | UTC

376,000 people in UK have had long Covid symptoms for at least a year – ONS – The Guardian

Original report: Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 4 June 2021 – Office for National Statistics

Practice Pointer | Mask related acne (“maskne”) and other facial dermatoses.

8 Jun, 2021 | 09:24h | UTC

Commentary on Twitter

The term “maskne” has become increasingly popular during the pandemic, particularly in the media.

This #BMJInfographic presents common distributions that can be used as a starting point for assessment @will_s_t https://t.co/mKQUaN3PYY pic.twitter.com/OCBuFxiY9s

— The BMJ (@bmj_latest) June 7, 2021

Synopsis | Updates to the Pediatrics Asthma Management Guidelines.

8 Jun, 2021 | 09:22h | UTC

Updates to the Pediatrics Asthma Management Guidelines – JAMA Pediatrics (free for a limited period)

Original Guideline: 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group

RCT: Low tidal volume ventilation is not superior to no ventilation during cardiopulmonary bypass in heart surgery.

8 Jun, 2021 | 09:16h | UTC

Low Tidal Volume Mechanical Ventilation Against No Ventilation During Cardiopulmonary Bypass in Heart Surgery (MECANO): A Randomized Controlled Trial – CHEST (link to abstract – $ for full-text)

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection – there was a significant association between skin rashes and a positive swab test result (odds ratio 1.67).

8 Jun, 2021 | 09:26h | UTC

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection – British Journal of Dermatology

Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicenter randomized control trial.

8 Jun, 2021 | 09:21h | UTC

Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicentre randomised control trial – Clinical Microbiology and Infections

Commentary on Twitter

??Analysis Data from RAPIDO RCT
Time to positivity is not associated with mortality, except in Candida spp (longer times associated with worse outcomes), and possibly in Streptococci (shorter times associated with worse outcomes) #IDTwitter #medtwitter https://t.co/v17uT8j7u9

— Antibiotic Steward ???Bassam Ghanem (@ABsteward) June 7, 2021