Daily Archives: May 24, 2021
CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
24 May, 2021 | 08:41h | UTCCommentaries: C.D.C. Is Investigating a Heart Problem in a Few Young Vaccine Recipients – The New York Times AND U.S. CDC looking into heart inflammation in some young vaccine recipients – Reuters
Related: Israel said probing link between Pfizer shot and heart problem in men under 30 – The Times of Israel
[Preprint] RCT: Both REGEN-COV 2400mg and 1200mg antibody cocktails significantly reduced Covid-19-related hospitalization or all-cause death compared to placebo (71.3% reduction and 70.4% reduction, respectively).
24 May, 2021 | 08:46h | UTCREGEN-COV Antibody Cocktail Clinical Outcomes Study in Covid-19 Outpatients – medRxiv
Commentary on Twitter
REGEN-COV Antibody Cocktail(casirivimab with imdevimab) Clinical Outcomes Study in Covid-19 Outpatients: N:>4000 pts
Both 1200mg IV&2400mg REGEN-COV led to a ≥70% ⬇️ (vs placebo) in Covid-19 hospitalization or all-cause death over 28 days after treatmenthttps://t.co/NJxF4BjZRs pic.twitter.com/CFdvEEIWEL— Antibiotic Steward ???Bassam Ghanem (@ABsteward) May 21, 2021
[Preprint] Pfizer and AstraZeneca Vaccines effective against B.1.617.2 variant after 2 doses.
24 May, 2021 | 08:42h | UTCNews release: Vaccines highly effective against B.1.617.2 variant after 2 doses – Public Health England
Original study: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant – Public Health England
Commentary: Covid: Pfizer and AstraZeneca jabs effective against Indian variant – study – BBC
[Preprint] Effectiveness of the CoronaVac vaccine in the elderly population during a P.1 variant-associated epidemic of COVID-19 in Brazil – “CoronaVac was 42% effective in the real-world setting of extensive P.1 transmission, but significant protection was not observed until completion of the two-dose regimen”.
24 May, 2021 | 08:43h | UTC
M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.
24 May, 2021 | 08:39h | UTC
Commentary on Twitter
Tocilizumab as IL-6 antagonist in hospitalized #COVID19 pts, SR/MA/TSA:
➡️10 RCTs/6493 pts (52.2% ➡️ tocilizumab)
➡️some evidence suggests tocilizumab may be associated with short-term mortality benefit
➡️tocilizumab may prevent disease progression to MVhttps://t.co/sWR4Y351sl pic.twitter.com/JPD31Nb5rn— Intens Care Med (@yourICM) May 22, 2021
WHO: The impact of COVID-19 on global health goals – COVID-19 responsible for at least 3 million excess deaths in 2020.
24 May, 2021 | 08:49h | UTCThe impact of COVID-19 on global health goals – World Health Organization
Related: Covid-19 pandemic: approximately one million excess deaths occurred in 2020 in 29 high income countries. AND Perspective | Tracking lives we’ve lost to COVID-19. AND COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter (thread – click for more)
? The latest World Health Statistics report finds that #COVID19 is responsible for at least 3 million excess deaths in 2020 ? https://t.co/yAXB5bzx1g#HealthData pic.twitter.com/DMd9fg69I2
— World Health Organization (WHO) (@WHO) May 21, 2021
Using resources wisely in the COVID-19 pandemic: an international list of Choosing Wisely recommendations.
24 May, 2021 | 08:36h | UTC
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.
24 May, 2021 | 08:38h | UTCCommentary: Scientists find new way of predicting COVID-19 vaccine efficacy – University of New South Wales
Commentary on Twitter (thread – click for more)
Just published @NatureMedicine: For 7 vaccines, the neutralizing antibody levels are highly predictive of the magnitude of clinical efficacy, support long term protection vs severe illness, and preserved efficacy vs variantshttps://t.co/ZQIrTQErMm pic.twitter.com/rUl9TMbVrC
— Eric Topol (@EricTopol) May 17, 2021
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – moderate-to-severe COVID-19 was associated with age 25 years and older, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus.
24 May, 2021 | 08:34h | UTC
Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
24 May, 2021 | 08:31h | UTC
Commentary on Twitter
*Strongly* recommend this comprehensive review of just how much COVID19 vaccines reduce the risk of transmitting the virus to others. Tell the hesitant: the vaccines protect both you and protect others — a lot! @mugecevik @AaronRichterman @EricMeyerowitz https://t.co/Cv3t3zNMRL pic.twitter.com/sOLAKKIJnQ
— Paul Sax (@PaulSaxMD) May 21, 2021
#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.
24 May, 2021 | 08:28h | UTCUltrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Renal Denervation for Resistant Hypertension Is Not Back on Track – “A systolic blood pressure (SBP) reduction of 4.5 mm Hg is not good enough—for an invasive procedure”. – Medscape (free registration required)
#ACC21 – Lessons from the ACC 2021 Meeting.
24 May, 2021 | 08:29h | UTCLessons from the ACC 2021 Meeting – by John Mandrola, MD
RCT: Among patients with pemphigus vulgaris, rituximab was superior to mycophenolate mofetil in producing sustained complete remission at 52 weeks (40% vs 10%) but was associated with increased risk of serious adverse events (22% vs. 15%).
24 May, 2021 | 08:24h | UTC
RCT: Endovascular therapy for stroke due to basilar-artery occlusion – “endovascular therapy and medical therapy did not differ significantly with respect to a favorable functional outcome”.
24 May, 2021 | 08:27h | UTCEndovascular Therapy for Stroke Due to Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)
A deep learning algorithm can estimate malignancy risk of pulmonary nodules detected at low-dose screening CT.
24 May, 2021 | 08:21h | UTCCommentaries: AI predicts lung cancer risk – Radiological Society of North America AND AI Takes LDCT Further for Lung Cancer Prediction – Diagnostic Imaging
Commentary on Twitter
A deep learning algorithm can have a discriminative performance comparable to that of clinical experts on low-dose screening chest CTs. https://t.co/60U518u6eA pic.twitter.com/phZPFDpUpx
— Radiology (@radiology_rsna) May 20, 2021
New Google AI tool can help patients identify common skin conditions.
24 May, 2021 | 08:23h | UTCUsing AI to help find answers to common skin conditions – Google
Commentary: Google AI tool can help patients identify skin conditions – BBC
The state of diabetes treatment coverage in 55 low-income and middle-income countries – fewer than one in ten people with diabetes in LMICs receive comprehensive care such as low-cost medicines to reduce blood sugar, blood pressure and cholesterol levels, in addition to counseling on diet, exercise and weight.
24 May, 2021 | 08:18h | UTCCommentary: Vast under-treatment of diabetes seen in global study – Michigan Medicine
[Preprint] No safe level of alcohol consumption for brain health: observational cohort study of 25,378 UK Biobank participants.
24 May, 2021 | 08:20h | UTCCommentaries: Drinking any amount of alcohol causes damage to the brain, study finds – CNN AND Expert reaction to a preprint looking at alcohol consumption and brain health – Science Media Centre AND Any amount of alcohol consumption harmful to the brain, finds study – The Guardian
Pessaries for pelvic organ prolapse – looking at the Cochrane evidence.
24 May, 2021 | 08:17h | UTCPessaries for pelvic organ prolapse – looking at the Cochrane evidence – Evidently Cochrane
Original Review: Pessaries (mechanical devices) for managing pelvic organ prolapse in women – Cochrane Library
Nonreplicable publications are cited more than replicable ones
24 May, 2021 | 08:15h | UTCNonreplicable publications are cited more than replicable ones – Science Advances
Commentary on Twitter
Not only does misinformation flow at considerably higher velocity across the Internet than truth, but science publications without replication are cited much more than those which are replicated
New @ScienceAdvances https://t.co/aNSKyv1alq @UriGneezy @m_serra_garcia pic.twitter.com/eWWc0NZwgi— Eric Topol (@EricTopol) May 21, 2021