Daily Archives: April 16, 2021 | LinksMedicus Free Medical News & Perspectives

RCT: Continued versus discontinued oxytocin stimulation in the active phase of labor

16 Apr, 2021 | 06:18h | UTC

Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): double blind randomised controlled trial – The BMJ

Commentaries: Study sheds more light on use of oxytocin during labour – The BMJ AND Study Explores Oxytocin Use in Active Phase of Induced Labor – HealthDay

Commentary on Twitter

#BMJInfographic #VisualAbstract Routine discontinuation of oxytocin stimulation in the active phase of labour may lead to a small increase in caesarean section rate but a reduced risk of uterine hyperstimulation and abnormal fetal heart rate patterns https://t.co/LbCxUf1MSx pic.twitter.com/BSQ5rrwQb5

— The BMJ (@bmj_latest) April 15, 2021

Phase 2 RCT: Psilocybin, a psychedelic compound, shows promise for the treatment of depression in a study with 59 patients

16 Apr, 2021 | 06:17h | UTC

Trial of Psilocybin versus Escitalopram for Depression – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Magic mushroom compound performs as well as antidepressant in small study – Imperial College London AND First-of-its-kind study pits psilocybin against a common antidepressan – STAT AND Psilocybin Not Significantly Different from Escitalopram for Depression – NEJM Journal Watch AND Expert reaction to phase 2 trial comparing psilocybin and escitalopram for depression – Science Media Centre

WHO: Global shortage of innovative antibiotics fuels emergence and spread of drug-resistance

16 Apr, 2021 | 06:20h | UTC

News release: Global shortage of innovative antibiotics fuels emergence and spread of drug-resistance – World Health Organization

Report: 2020 antibacterial agents in clinical and preclinical development: an overview and analysis – World Health Organization

Commentary: WHO report highlights shortage of new antibiotics – CIDRAP

Hemodialysis Emergencies: Core Curriculum 2021

16 Apr, 2021 | 06:13h | UTC

Hemodialysis Emergencies: Core Curriculum 2021 – American Journal of Kidney Diseases

Commentary on Twitter

Hemodialysis Emergencies: Core Curriculum 2021https://t.co/BOQrsABOU3 (FREE)@KeikoGNeph @Mike_J_Choi @MedStarGUH #Hemodialysis pic.twitter.com/KYZRCqm5OA

— AJKD (@AJKDonline) March 26, 2021

RCT: An Enhanced Recovery After Surgery (ERAS) program in laparoscopic distal gastrectomy provided a faster recovery, a shorter postoperative hospitalization length, and lower medical costs without increasing complication and readmission rates

16 Apr, 2021 | 06:16h | UTC

Randomized Controlled Trial Comparing the Short-term Outcomes of Enhanced Recovery After Surgery and Conventional Care in Laparoscopic Distal Gastrectomy – Annals of Surgery

Study shows antihistamines may impair response to exercise training

16 Apr, 2021 | 06:06h | UTC

Histamine H₁ and H₂ receptors are essential transducers of the integrative exercise training response in humans – Science Advances

Commentary: Histamine-suppressing drugs found to reduce benefits of exercise – MedicalXpress

Commentary on Twitter (thread – click for more)

Extremely excited to finally share our newest paper: Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. Published today in @ScienceAdvances. A thread: (1/12)https://t.co/R4FNiKWyG9 pic.twitter.com/U2HFHOY9eA

— Thibaux Van der Stede (@ThibauxV) April 14, 2021

Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials

16 Apr, 2021 | 06:14h | UTC

Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials – Advances in Therapy

[Preprint] Risk of rare blood clotting much higher for COVID-19 than for vaccines

16 Apr, 2021 | 06:37h | UTC

News release: Risk of rare blood clotting higher for COVID-19 than for vaccines – University of Oxford

Original study (preprint): Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine

Commentaries: Brain clots ‘more likely’ with Covid infection than vaccine – BBC AND Risk for Cerebral Venous Thrombosis Elevated After COVID-19 Diagnosis – NEJM Journal Watch AND Study: COVID much more likely than vaccines to cause blood clots – CIDRAP

Commentary on Twitter

There is an interesting new preprint out that will probably generate a lot of coverage at least in the UK. Essentially it argues that the risk of CVST is much higher from #covid19 than from vaccines.
Quick thread on this:https://t.co/0MdDU2z9bp

— Kai Kupferschmidt (@kakape) April 15, 2021

Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months

16 Apr, 2021 | 06:35h | UTC

Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months – Intensive Care Medicine

Commentary on Twitter

Our paper on covid-19 pandemic trends in the first 8 months in the pandemic at @yourICM. Patients are getting younger, less frail, and mortality decreased over time. Very poor outcomes for elder frail patients. https://t.co/DHJvr22zFl

— Fernando Zampieri (@f_g_zampieri) April 14, 2021

CDC study suggests leaving middle seat empty could lower COVID-19 spread on planes by 23% to 57%

16 Apr, 2021 | 06:33h | UTC

Laboratory Modeling of SARS-CoV-2 Exposure Reduction Through Physically Distanced Seating in Aircraft Cabins Using Bacteriophage Aerosol — November 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: Keeping middle seats vacant on airplanes can reduce risk of Covid-19 exposure by up to 57%, CDC study says – CNN AND Leaving middle seat empty lowers COVID-19 spread on planes, modeling suggests – LiveScience

M-A: Treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients

16 Apr, 2021 | 06:30h | UTC

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials – Nature Communications

Commentaries on Twitter

The use of hydroxychloroquine in COVID19 will be remembered as one of the worst examples of medicine going against its core principle:
First Do No Harm. https://t.co/PGq4D5pJ1H

— Maurizio Cecconi (@DrMCecconi) April 15, 2021

What collaboration can achieve

Just out in @NatureComms our meta-analysis of 14 unpublished & 14 published RCTs on Hydroxychloroquine/ Choloroquine

Thanks so much to the great team – and special thanks for rapidly sharing the data of unpublished trials!https://t.co/Dg1DmAx1Kq

— Lars G. Hemkens (@LGHemkens) April 15, 2021