Daily Archives: February 7, 2021
RCT: In patients with cirrhosis treated with TIPS, prophylactic rifaximin reduced the risk for Hepatic Encephalopathy
7 Feb, 2021 | 21:10h | UTCThe Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rifaximin prevents overt hepatic encephalopathy after TIPS – HealthDay
Commentary on Twitter
New findings published in @AnnalsofIM:
In patients with #cirrhosis treated with TIPS, rifaximin was well tolerated and reduced the risk for overt HE. #Rifaximin should therefore be considered for prophylaxis of post-TIPS HE https://t.co/d2p9dfcx3s. pic.twitter.com/M7zwmUxQA3
— Annals of Int Med (@AnnalsofIM) February 2, 2021
RCT: Posaconazole noninferior to voriconazole for primary treatment of invasive aspergillosis
7 Feb, 2021 | 21:00h | UTCPosaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
RCT: Enteral lipid supplement reduces the risk of severe retinopathy of prematurity
7 Feb, 2021 | 21:04h | UTCCommentary: Halved risk for severe retinal disease in extremely premature infants – University of Gothenburg
Commentary on Twitter
A new study at #jamapeds reports that enteral fatty acid supplementation with AA and DHA lowers the risk of retinopathy of prematurity among extremely preterm infants. https://t.co/skN41O2YX4 pic.twitter.com/c9bv3V6wbn
— JAMA Pediatrics (@JAMAPediatrics) February 4, 2021
SR/MA: Up to a third of patients may discontinue thyroid hormone replacement and remain euthyroid
7 Feb, 2021 | 21:02h | UTCClinical Outcomes After Discontinuation of Thyroid Hormone Replacement: A Systematic Review and Meta-Analysis – Thyroid (link to abstract – $ for full-text)
Commentary: A Third Discontinuing Levothyroxine Have Normal Thyroid Levels – Medscape (free registration required)
Commentaries on Twitter
Hard to believe that simply treating hypothyroidism may fit into “Things We Do For No Reason.”
But >1/3 of people on thyroid replacement stay euthyroid after stopping meds.
See article for results, predictors of euthyroidism, & de-escalation strategies.https://t.co/i1f04FnbPk pic.twitter.com/fGLAbjNo5B
— David A. Cohen (@DavidACohen_MD) January 21, 2021
(thread – click for more)
#endocation #endotwitter #endotips #endorules
Hypothyroidism?: Third of Patients Treated for
Hypothyroidism May Not Require Thyroid Hormones❗️https://t.co/iAZcwFB5Ul✅Hypothyroidism: 5% of population, age dependent
✅NHANES: 6.4% reported use of levothyroxine (LT4)1/
— Fady Hannah-Shmouni, MD FRCPC (@DrShmouni) January 14, 2021
Guideline synopsis: Management of immunotherapy-related toxicities in patients treated with immune checkpoint inhibitor therapy
7 Feb, 2021 | 20:55h | UTCManagement of Immunotherapy-Related Toxicities in Patients Treated With Immune Checkpoint Inhibitor Therapy – JAMA (free for a limited period)
Audio Clinical Review: Management of Immunotherapy-Related Toxicities
Original guideline and other resources: NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities
Prospective validation of Canadian TIA Score for subsequent stroke risk after transient ischemic attack
7 Feb, 2021 | 20:54h | UTCSee calculator: Canadian TIA Score
Commentary on Twitter
Jeff Perry is at it again! The ABCD2 score lacks the ability to discriminate low and high risk patients following TIA, so Perry et al. have validated the Canadian TIA Score.
Infographic and bedside calculator: https://t.co/OcbaK1aG3t
Full publication: https://t.co/wt87PKzNkO pic.twitter.com/q3QdgVxp6x
— EM Ottawa (@emergmedottawa) February 4, 2021
Survey: Prevalence of and factors associated with nurse burnout in the US
7 Feb, 2021 | 20:51h | UTCPrevalence of and Factors Associated With Nurse Burnout in the US – JAMA Network Open
Commentary: Nurse Burnout Remains an Issue in the United States – HealthDay
Commentary on Twitter
Survey finds over 30% of nurses who left their jobs in 2017 reported burnout; working in the hospital and over 40 hours per week increased the odds of leaving due to burnout. @mkali80 @emoryhealthcare https://t.co/R6TYPtANeZ
— JAMA Network Open (@JAMANetworkOpen) February 4, 2021
Israel outpaced the world in vaccinations. Now it’s seeing the results
7 Feb, 2021 | 21:26h | UTCIsrael outpaced the world in vaccinations. Now it’s seeing the results – Vox
See also: Covid-19: Israel sees new infections plummet following vaccinations – The BMJ AND Israel says vaccine has almost halved COVID cases among over-60s – Reuters AND Vaccines are curbing COVID: Data from Israel show drop in infections – Nature AND Israel’s vaccination rollout: short term success, but questions for the long run – The BMJ Opinion
Case report: SARS-CoV-2 evolution in immunocompromised patient treated with convalescent plasma
7 Feb, 2021 | 21:32h | UTCSARS-CoV-2 evolution during treatment of chronic infection – Nature
Commentary on Twitter
Just published @nature: The evolution of #SARSCoV2 in an immunocompromised patient, over > 100 days, that markedly accelerated once treated w/ convalescent plasma, with mutations that altered the response to neutralizing antibodies, by @GuptaR_lab https://t.co/SI4QL6BRXe pic.twitter.com/wqI1C2EYjQ
— Eric Topol (@EricTopol) February 5, 2021
[Press release – not published yet] Sinovac Announces Phase III Results of Its COVID-19 Vaccine
7 Feb, 2021 | 21:29h | UTCSinovac Announces Phase III Results of Its COVID-19 Vaccine
Commentaries: Expert reaction to announcement of results of phase III of Sinovac vaccine in China – Science Media Centre AND Sinovac says COVID-19 vaccine effective in preventing hospitalization, death – Reuters
Commentary on Twitter (thread – click for more)
Sinovac's CoronaVac's phase 3 trial results: some data from Turkey in press release. Brazilian trial, much as Brazil announced: 50.65% vaccine efficacy for all symptomatic disease, 83.7% for people requiring medical care – & no severe or fatal disease..1/n https://t.co/dsCvQZAGKe
— Hilda Bastian, PhD (@hildabast) February 6, 2021
[Press release – not published yet] Covid-19: Oxford vaccine offers less protection against South Africa variant
7 Feb, 2021 | 21:25h | UTCOxford Covid-19 vaccine trial results – University of the Witwatersrand
Commentaries: Covid: Oxford jab offers less S Africa variant protection – BBC AND Expert reaction to news reports that the Oxford/AZ vaccine gives limited protection against mild disease caused by the South African variant of SARS-CoV-2 – Science Media Centre AND Oxford/AstraZeneca COVID shot less effective against South African variant: study – Reuters
Commentary on Twitter (thread – click for more)
[Thread] 1. NEW Early data (not yet peer reviewed) shows the #AstraZeneca #CovidVaccine, that SA will start to administer this month, doesn't appear to offer protection against mild/moderate disease caused by the #501YV2 variant identified in the country. https://t.co/UWD0Xilner
— Mia Malan (@miamalan) February 7, 2021
Editorial: What went wrong in the global governance of covid-19?
7 Feb, 2021 | 21:27h | UTCWhat went wrong in the global governance of covid-19? – The BMJ
Related: The Five Things to Get Right Before the Next Pandemic – Bloomberg AND International collaboration and covid-19: what are we doing and where are we going? – The BMJ AND Why did the world’s pandemic warning system fail when COVID hit? – Nature AND One Year Later: COVID-19 Versus WHO And The World – Successes, Failures & Hopes – Health Policy Watch AND WHO’s Covid warnings were not heeded. Now the world has a new chance to beat the virus – The Guardian
The good and the (potentially) bad: What scientists know about variants and Covid-19 vaccines
7 Feb, 2021 | 21:23h | UTCThe good and the (potentially) bad: What scientists know about variants and Covid-19 vaccines – STAT
See also: What Will it Take to Make Covid-19 Vaccines Variant-Proof? – Wired AND What’s Going On With All These Coronavirus Variants? An Illustrated Guide – NPR AND Video: Coronavirus Variants – What They Mean – JAMA
SR/MA: ICU mortality from COVID-19 continued to fall in 2020, but improvement is slowing
7 Feb, 2021 | 21:18h | UTCNews release: ICU mortality from COVID-19 continued to fall in 2020, but improvement is slowing – University of Bristol
Original article: Mortality in patients admitted to intensive care with COVID‐19: an updated systematic review and meta‐analysis of observational studies – Anaesthesia
Commentary on Twitter
?Has mortality from COVID‐19 in patients admitted to the ICU changed again?@drrichstrong, @adk300, @emirakur and @doctimcook update their previous analysis and find that any fall in mortality rate between June and September appears to have plateaued.
?https://t.co/zp8ygzp78A pic.twitter.com/g21p3rcjY6
— ??????????? (@Anaes_Journal) February 2, 2021
Cohort study: ECMO in patients with severe respiratory failure from COVID-19
7 Feb, 2021 | 21:16h | UTCRelated: ECMO for COVID-19 patients in Europe and Israel – Intensive Care Medicine
Commentaries on Twitter
#ECMO in #COVID19, multicenter US based study on 5122 critical adults
➡️#ECLS in 3.7%, 66.8% of whom survived to hospital discharge or 60 days
➡️considerably reduced mortality with early ECMO in severe hypoxemic respiratory failure vs conventional approachhttps://t.co/OgS7Q5tctS pic.twitter.com/PO5O8t3l8F— Intens Care Med (@yourICM) February 4, 2021
Online today @yourICM, our important multicenter descriptive and trial emulation work around #ECMO and #COVID19 @BIDMCAnesthesia @DavidLeaf9 @SamanthaSkb273 @_MiguelHernan from the STOP-COVID Investigators https://t.co/DuhWufYqZ3 pic.twitter.com/nXPvKDYMYL
— Shaz Shaefi (@SShaefi) February 2, 2021
What’s the risk of dying from a fast-spreading COVID-19 variant?
7 Feb, 2021 | 21:21h | UTCWhat’s the risk of dying from a fast-spreading COVID-19 variant? – Nature
Original study: Increased hazard of death in community-tested cases of SARS-CoV-2 Variant of Concern 202012/01 – medRxiv
Review: “Silent” Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19
7 Feb, 2021 | 21:13h | UTC“Silent” Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19 – Anesthesia
Report: The state of the world’s antibiotics report in 2021
7 Feb, 2021 | 20:49h | UTCCommentary: Report highlights lack of progress against antimicrobial resistance – CIDRAP
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
7 Feb, 2021 | 20:47h | UTCCommentaries: Breast cancer tops lung cancer as most diagnosed cancer in the world, new report says – CNN AND Breast Cancer Tops Lung Cancer for No. 1 Diagnosis Worldwide – Diagnostic Imaging
Related: Breast cancer now most common form of cancer: WHO taking action – World Health Organization
Commentary on Twitter
For the first time, female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer in the world according to the latest @AmericanCancer & @IARCWHO report. https://t.co/SmX8czB4Wx #GlobalCancerStats?️#WorldCancerDay pic.twitter.com/IUMFkMUzx2
— CA: A Cancer Journal for Clinicians (@CAonline) February 4, 2021
Clinical Cancer Advances 2021: ASCO’s Report on Progress Against Cancer
7 Feb, 2021 | 20:45h | UTCCommentary: ASCO Names Molecular Profiling in GI Cancers as Advance of the Year – OncLive