Daily Archives: December 11, 2020
Just published: Pfizer vaccine confers 95% protection against Covid-19
11 Dec, 2020 | 09:32h | UTCSafety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine – New England Journal of Medicine
Editorial: SARS-CoV-2 Vaccination — An Ounce (Actually, Much Less) of Prevention
Commentary: Pfizer vaccine results published in peer-reviewed journal – MedicalXpress
Related: FDA advisory panel endorses Pfizer/BioNTech Covid-19 vaccine – STAT
Commentary on Twitter (Thread – Click for more)
I read the @pfizer @US_FDA vaccine briefing doc
3 take homes (1 obvious, 2 new takes I haven't seen before)
1. Efficacy is great to prevent #COVID19 & promising for severe illness (this has been said many times before)
Moving on…https://t.co/WLrEpjmuO8
— Anil Makam (@AnilMakam) December 10, 2020
Healthcare workers 7 times as likely to have severe COVID-19 as other workers
11 Dec, 2020 | 09:29h | UTCCommentary: Healthcare workers 7 times as likely to have severe COVID-19 as other workers – BMJ
Commentary on Twitter
Of essential workers, who has the highest risk of severe #COVID19?
Healthcare workforce >7X.
Non-white >8X.https://t.co/ZBUJYccXlT (compared with non-essential workers)
A @uk_biobank study from >120,000 participants
[NB: current issue with link] pic.twitter.com/UZmIO69G4O— Eric Topol (@EricTopol) December 9, 2020
Randomized trial: No difference in quality of life and slightly greater weight loss with Roux-en-Y Gastric Bypass compared to Laparoscopic Sleeve Gastrectomy at 7 years
11 Dec, 2020 | 09:20h | UTCEffect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss and Quality of Life at 7 Years in Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Using Quality-of-Life Measures to Determine the Ideal Bariatric Procedure – JAMA Surgery (free for a limited period)
WHO reveals leading causes of death and disability worldwide: 2000-2019
11 Dec, 2020 | 09:24h | UTCWHO reveals leading causes of death and disability worldwide: 2000-2019 – World Health Organization
Fact Sheet: The top 10 causes of death
Long Covid: Study shows persistence of symptoms in a third of ambulatory patients 30 to 45 days after diagnosis
11 Dec, 2020 | 09:27h | UTCCommentary: COVID-19: persistent symptoms in one third of cases – Université de Genève
Commentary on Twitter
Study of 669 people who had #COVID19 during the first wave in Switzerland. Of 510 who were followed up for 30-45 days, 32% still had at least one symptom.
Fatigue, shortness of breath, and loss of smell or taste were the most common symptoms. #LongCovidhttps://t.co/pDB6nuZWTn pic.twitter.com/bbt9c3LFXl
— Dr Zoë Hyde (@DrZoeHyde) December 8, 2020
Review: Mechanical complications of acute myocardial infarction
11 Dec, 2020 | 09:19h | UTCMechanical Complications of Acute Myocardial Infarction: A Review – JAMA Cardiology
Videos: Acute Rupture of Left Ventricular Aneurysm AND Ventricular Septal Rupture AND Papillary Muscle Rupture
British HIV Association guidelines on the management of gastrointestinal opportunistic infections in people living with HIV
11 Dec, 2020 | 09:16h | UTC
Randomized trial: Among patients in the ICU receiving invasive ventilation, a strategy with lower PEEP was noninferior to a strategy using higher PEEP
11 Dec, 2020 | 09:22h | UTCEditorial: Searching for the Optimal PEEP in Patients Without ARDS: High, Low, or in Between?
Video: Effect of Lower vs Higher PEEP Strategy on Ventilator-Free Days in ICU Patients Without ARDS
Commentary on Twitter
Effect of a Lower vs Higher PEEP Strategy on Ventilator-Free Days in ICU Patients Without ARDS https://t.co/h6IozSLUeS via @JAMA_current part of @JAMANetwork There is no size that fits all. PEEP titration – way to go.
— Matthias Eikermann (@MatthiasEikerm1) December 10, 2020
Systematic Review: Financial conflicts of interest are associated with favorable recommendations of drugs and devices in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews
11 Dec, 2020 | 09:18h | UTC
Randomized trial: Long-acting injectable antipsychotic use by patients with early-phase schizophrenia can significantly delay time to first hospitalization
11 Dec, 2020 | 09:14h | UTCCommentary: Long-Acting Injectable Antipsychotics vs. Usual Care for Early-Phase Schizophrenia – Physician’s Weekly
Commentary on Twitter
RCT: The mean survival time until 1st hospitalization was 613.7 days for patients with schizophrenia treated with aripiprazole once monthly vs. 530.6 days for those treated with usual care (HR=0.56; 0.34- 0.92; NNT=7) https://t.co/i3857D2ULQ
— PfOL (@psychopharmacol) December 5, 2020