Daily Archives: August 14, 2020 | LinksMedicus Free Medical News & Perspectives

Randomized trial: Methylprednisolone as adjunctive therapy for patients hospitalized with COVID-19

14 Aug, 2020 | 01:53h | UTC

Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With COVID-19 (Metcovid): A Randomised, Double-Blind, Phase IIb, Placebo-Controlled Trial – Clinical Infectious Diseases

Commentary on Twitter

Metcovid Double Blind PH. 2
RCT ??~ 400 pts #CID
Methylprednisolon 0.5mg/kg twice daily x5d #COVID19 Hospitalized pts #COVID19 did not reduce 28d mortality V placebo
Is it Right Drug, Dose, Duration
High dose vs RECOVERY
DEX less mineralocorticoid
5 v 10 https://t.co/EBIRWYouSQ pic.twitter.com/OzGJkqjkrJ

— Antibiotic Steward? Bassam Ghanem (@ABsteward) August 13, 2020

Fauci says coronavirus temperature checks ‘notoriously inaccurate’

14 Aug, 2020 | 01:49h | UTC

Fauci Says Coronavirus Temperature Checks ‘Notoriously Inaccurate’ – Forbes

These Covid-19 vaccine candidates could change the way we make vaccines — if they work

14 Aug, 2020 | 01:43h | UTC

These Covid-19 vaccine candidates could change the way we make vaccines — if they work – Vox

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes

14 Aug, 2020 | 01:44h | UTC

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials – JAMA

Commentary on Twitter

Inactivated #COVID19 #vaccine had a low rate of adverse reactions and demonstrated immunogenicity, but longer-term assessment of safety and efficacy will require phase 3 trials https://t.co/atmhXFFHSw

— JAMA (@JAMA_current) August 13, 2020

Coagulopathy in COVID-19: Manifestations and management

14 Aug, 2020 | 01:21h | UTC

Coagulopathy in COVID-19: Manifestations and management – Cleveland Clinic Journal of Medicine

There’s ‘no evidence’ of foodborne transmission of COVID-19, says WHO

14 Aug, 2020 | 01:52h | UTC

There’s ‘No Evidence’ Of Foodborne Transmission Of COVID-19, Says WHO – Health Policy Watch

[Preprint] Observational study: Effect of convalescent plasma on mortality among hospitalized patients with COVID-19

14 Aug, 2020 | 01:24h | UTC

Effect of Convalescent Plasma on Mortality among Hospitalized Patients with COVID-19: Initial Three-Month Experience – medRxiv

Commentary: Large study suggests convalescent plasma can help treat Covid-19, but experts have doubts – STAT

Commentary on Twitter

? Preliminary results from convalescent plasma Expanded Access Program ?

35,322 patients ?

Not an RCT ?

But, lower mortality with earlier administration & higher antibody titre support possible efficacy ?https://t.co/xwzz3mQ0qX pic.twitter.com/Utquky4wW1

— Ilan Schwartz MD PhD (@GermHunterMD) August 13, 2020

Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19

14 Aug, 2020 | 01:17h | UTC

Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19 – PLOS One

Commentary: New prediction model can forecast personalized risk for COVID-19-related hospitalization – MedicalXpress

Online risk calculator: Predict Hospitalization Risk for COVID-19 Positive

Study: Household contact is the primary setting for transmission of SARS-CoV-2

14 Aug, 2020 | 01:22h | UTC

Contact Settings and Risk for Transmission in 3410 Close Contacts of Patients With COVID-19 in Guangzhou, China: A Prospective Cohort Study – Annals of Internal Medicine

Comparison of estimated excess deaths in New York City during the COVID-19 and 1918 Influenza pandemics

14 Aug, 2020 | 01:14h | UTC

Comparison of Estimated Excess Deaths in New York City During the COVID-19 and 1918 Influenza Pandemics – JAMA Network Open

Commentary: COVID-19 deaths in NYC ‘comparable’ to 1918-1919 flu pandemic – UPI

CDC Study: Covid-19 pandemic linked to worse mental health outcomes, increased substance use, and elevated suicidal ideation

14 Aug, 2020 | 01:14h | UTC

Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic — United States, June 24–30, 2020 – CDC Morbidity and Mortality Weekly Report

Commentary: CDC study sheds new light on mental health crisis linked to coronavirus pandemic – CNN

Randomized trial: Effect of mammographic screening from age 40 years on breast cancer mortality

14 Aug, 2020 | 01:09h | UTC

Effect of mammographic screening from age 40 years on breast cancer mortality (UK Age trial): final results of a randomised, controlled trial – The Lancet Oncology

Commentaries: Study revives debate over breast cancer screening age – The Guardian AND Expert reaction to study looking at breast screening women in their 40s and cancer deaths – Science Media Centre AND Final results of the UK Age trial on breast cancer screening age – The Lancet Oncology

[Abstract Only] Randomized trial: Compression therapy to prevent recurrent cellulitis of the leg

14 Aug, 2020 | 01:08h | UTC

Compression Therapy to Prevent Recurrent Cellulitis of the Leg – New England Journal of Medicine

Commentaries: Benefit Seen With Compression Therapy to Prevent Recurrent Cellulitis – Physician’s Weekly AND NEJM: Compression Therapy Prevention of Recurrent Cellulitis Without Antibiotics – MedicalResearch.com

Systematic review: The use of erythropoietin plus iron to correct anemia before surgery to reduce the risk of blood transfusion

14 Aug, 2020 | 01:04h | UTC

Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non‐cardiac surgery – Cochrane Library

Summary: The use of erythropoietin plus iron to correct anaemia before surgery to reduce the risk of blood transfusion – Cochrane Library

UNICEF/WHO Report: 2 in 5 schools around the world lacked basic handwashing facilities prior to COVID-19

14 Aug, 2020 | 01:11h | UTC

2 in 5 schools around the world lacked basic handwashing facilities prior to COVID-19 pandemic — UNICEF, WHO

Report: Progress on drinking-water, sanitation and hygiene in schools – World Health Organization

Report Highlights: Progress on drinking-water, sanitation and hygiene in schools – World Health Organization

[Abstract Only] Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

14 Aug, 2020 | 01:06h | UTC

Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trial – JAMA

Commentary: When should we transfuse preterm babies, and why? – Neonatal Research

Commentary on Twitter

Among extremely low-birth-weight infants, a liberal blood transfusion strategy did not reduce the likelihood of death or disability at 24 months compared with a restrictive strategy #VisualAbstract https://t.co/75YAhZx6au

— JAMA (@JAMA_current) August 12, 2020

[Abstract Only] Randomized trial: Intravenous lidocaine for the prevention of postoperative catheter-related bladder discomfort in male patients undergoing transurethral resection of bladder tumors

14 Aug, 2020 | 01:03h | UTC

Intravenous Lidocaine for the Prevention of Postoperative Catheter-Related Bladder Discomfort in Male Patients Undergoing Transurethral Resection of Bladder Tumors: A Randomized, Double-Blind, Controlled Trial – Anesthesia & Analgesia

Commentary on Twitter

IV #lidocaine administration resulted in lower incidence of moderate-to-severe CRBD, lower #opioid requirement, & higher #PatientSatisfaction in males undergoing TURBT without evidence of significant side effects @cuhpr https://t.co/OPOGkZl2Dd pic.twitter.com/RjcRP8UzlA

— Anesthesia&Analgesia (@IARS_Journals) July 10, 2020