Daily Archives: October 27, 2019
Analysis: Is Mycobacterium Tuberculosis Infection Life Long?
27 Oct, 2019 | 23:44h | UTCIs Mycobacterium tuberculosis infection life long? – The BMJ (free)
Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)
Related Commentary on Twitter
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis. Is this assumption valid? Marcel A Behr and colleagues argue that most of these people are no longer infected https://t.co/LlRcMNlriJ
— The BMJ (@bmj_latest) October 27, 2019
Opinion – “Sepsis Hysteria: Excess Hype and Unrealistic Expectations”
27 Oct, 2019 | 23:49h | UTCSepsis hysteria: excess hype and unrealistic expectations – The Lancet (free)
Commentary: Sepsis myths create ‘unhealthy climate of fear’, say experts – The Guardian (free)
Source: Grupo UTIclínica – HCFMUSP
Related Commentary on Twitter
"It is crucial to expose the fictions surrounding #sepsis…to create realistic expectations about outcomes"
Sepsis hysteria: NEW Correspondence from M Singer, M Inada-Kim & M Shankar-Hari https://t.co/3oVYkE1BQS pic.twitter.com/gMvdVyCicc
— The Lancet (@TheLancet) October 25, 2019
Things We Do for No Reason: Supplemental Oxygen for Patients without Hypoxemia
27 Oct, 2019 | 23:40h | UTCSee other articles in the series: Choosing Wisely: Things We Do For No Reason (free)
Related: Oxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free) AND Oxygen Treatment in Intensive Care and Emergency Medicine – Deutsches Ärzteblatt International (free) AND Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary) AND A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? – BioMed Research International (free)
Hospital Medicine Update: High-Impact Literature from March 2018 to April 2019
27 Oct, 2019 | 23:42h | UTC
Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis
27 Oct, 2019 | 23:39h | UTCSee other articles in the series: Choosing Wisely: Things We Do For No Reason (free)
Machine Learning Approaches to Predict 6-Month Mortality Among Patients with Cancer
27 Oct, 2019 | 23:34h | UTCCommentary: Algorithm Identifies Cancer Patients in Need of Advance Care Planning Conversations – Penn Medicine (free)
Perspective: Older Patients (Still) Left Out of Cancer Clinical Trials
27 Oct, 2019 | 23:36h | UTCOlder Patients (Still) Left Out of Cancer Clinical Trials – JAMA (free for a limited period)
Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)
Related Commentary on Twitter
Medication without representation: People 65 years or older are strikingly underrepresented in cancer clinical trials, even though most cancers occur in that age group. Via @JAMA_current https://t.co/IxWBqHAZIB pic.twitter.com/67YxklJIs1
— Muin J. Khoury (@MuinJKhoury) October 26, 2019
Redesigning Care for Older People to Preserve Physical and Mental Capacity
27 Oct, 2019 | 19:33h | UTCRelated: World report on ageing and health – World Health Organization (free)
Interest in Cannabidiol Products Keeps Soaring Despite Limited Evidence in Humans
27 Oct, 2019 | 19:29h | UTCTrends in Internet Searches for Cannabidiol (CBD) in the United States – JAMA Network Open (free)
Commentaries: Interest in CBD products keeps soaring, but health experts wary – HealthDay (free) AND Online Searches For CBD Skyrocket – MedicalResearch.com (free)
Related Commentary on Twitter
"Interest in CBD products keeps soaring, but health experts wary" https://t.co/TP50a31bbP via @medical_xpress
"At this time there are no known benefits for taking CBD over-the-counter. #CBD is this generation's snake oil…"
Studies "in humans are still limited…"#CBDHype.
— Timothy Caulfield (@CaulfieldTim) October 25, 2019
Report: Safe Ambulatory Care, Strategies for Patient Safety and Risk Reduction
27 Oct, 2019 | 23:33h | UTCNews Release: ECRI Institute: Diagnostic Tests, Medication Pose Biggest Risks to Patients in Ambulatory Care (free)
Commentaries: ECRI Institute: Top 4 Biggest Risks in Ambulatory Care to Watch – HIT Consultant Media (free) AND Top 5 Patient Safety Risks in Ambulatory Care – Medscape (free registration required)
Cohort Study: Association of Treatment With 5α-Reductase Inhibitors and Prostate Cancer Mortality
27 Oct, 2019 | 19:27h | UTCCommentary: Association between 5α-reductase inhibitors, prostate cancer mortality replicated – Medicine Matters (free)
Related Study: Use of 5α-reductase Inhibitors is Associated with Delayed Prostate Cancer Diagnosis and Increased Mortality in Men Undergoing PSA Screening (link to abstract and commentary)
Imaging in ESC Clinical Guidelines: Chronic Coronary Syndromes
27 Oct, 2019 | 19:23h | UTCOriginal Guideline: 2019 ESC Guidelines for the Diagnosis and Management of Chronic Coronary Syndromes (free)
Buying Birth Control Pills Online May Be Safe, Efficient
27 Oct, 2019 | 19:21h | UTCBuying birth control pills online may be safe, efficient – Reuters (free)
Original Research: A Study of Telecontraception – New England Journal of Medicine ($)
[Abstract Only] Randomized Trial: Regional or General Anesthesia Do Not Differ in Respect to Breast Cancer Recurrence or Persistent Incisional Pain
27 Oct, 2019 | 19:20h | UTCRecurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Anesthesia for breast cancer surgery has no influence on risk of tumor recurrence – Medical University of Vienna (free) AND Anesthesia Technique Flops in Large Breast Cancer Trial – MedPage Today (free registration required)
Related Commentary on Twitter
Latebreaking at #ANES2019—Regional anaesthesia-analgesia (paravertebral block & propofol) did not reduce #breastcancer recurrence after potentially curative surgery compared with volatile anaesthesia (sevoflurane) & opioids: a randomised controlled trial https://t.co/FlXaX0VieY pic.twitter.com/dBlRUNL6vl
— The Lancet (@TheLancet) October 20, 2019
Myocardial Fibrosis: Why Image, How to Image and Clinical Implications
27 Oct, 2019 | 19:22h | UTCMyocardial fibrosis: why image, how to image and clinical implications – Heart (free)
[Abstract Only] Randomized Trial: Anesthetic Depth and Complications After Major Surgery
27 Oct, 2019 | 19:18h | UTCAnaesthetic depth and complications after major surgery: an international, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
ICYMI @ #ANES19—Anaesthetic depth and complications after major surgery: an international, randomised controlled trial
Free to read with reg (also free) until Mon October 28 https://t.co/WBSZFg64PZ https://t.co/N8DsXgc89E
— The Lancet (@TheLancet) October 22, 2019
Cohort Study: Transmissibility and Potential for Disease Progression of Drug Resistant Mycobacterium Tuberculosis
27 Oct, 2019 | 19:15h | UTCCommentary: Peruvian study finds MDR-TB just as transmissible as drug-sensitive TB – CIDRAP (free – 2nd commentary)
Perspective: 12 Innovations That Will Change Health Care and Medicine in the 2020s
27 Oct, 2019 | 19:16h | UTC12 Innovations That Will Change Health Care and Medicine in the 2020s – TIME (free)
Related Commentary on Twitter
"12 Innovations That Will Change Health Care and Medicine in the 2020s" https://t.co/qFa5lnUK7S
First, many of these will not happen. Science so much slower & > unpredictable than often portrayed.
Second, unclear whether some would even be beneficial.
Still, #GoScience!
— Timothy Caulfield (@CaulfieldTim) October 25, 2019