Daily Archives: October 15, 2019
Tue October 15 – 10 Stories of The Day!
15 Oct, 2019 | 11:09h | UTC
Commentaries: CRASH-3: a win for patients with traumatic brain injury – The Lancet (free) AND Global trial is first clear evidence that a widely available drug reduces head injury deaths – London School of Hygiene & Tropical Medicine (free) AND PulmCrit- Tranexamic acid for traumatic brain injury (CRASH3) (free) AND CRASH-3! – Emergency Medicine Literature of Note (free) AND Head injuries: Cheap drug ‘could save thousands of lives a year’ – BBC (free) AND Common drug could prevent thousands of head injury deaths – The Guardian (free)
Related: Evidence Review: Tranexamic Acid (TXA) for Everything that Bleeds? (free resources on the subject)
2 – Conservative Oxygen Therapy during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: No clear benefit from conservative oxygen in mechanical ventilation – CHEST Physician (free) AND Trial: No Need for Intensive Oxygen in the ICU – MedPage Today (free registration required)
Related: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine (free) AND Diabetic foot – The BMJ (free) AND Diagnosis and Management of Diabetic Foot Complications – American Diabetes Association (free) AND Prevention, assessment, diagnosis and management of diabetic foot based on clinical practice guidelines: A systematic review – Medicine (free)
4 – Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-pharmacologic treatments may be more effective for psychiatric symptoms of dementia – St. Michael’s Hospital (free) AND To ease dementia agitation, drugs may not be best option – Reuters (free)
5 – Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Rivaroxaban Not Noninferior to VKAs for Antiphospholipid Antibody Syndrome – NEJM Journal Watch (free) AND DOAC Disappoints in Thrombotic Autoimmune Disorder – MedPage Today (free registration required)
Commentary: Ingestible sensor allows patients to be independent but still supported during TB treatment – Specialists in Global Health (free)
See also: Episodes List
8 – Management of Itch in the Elderly: A Review – Dermatology and Therapy (free)
9 – Youth suicide attempts often involve over-the-counter painkillers – Reuters (free)
Original Study: Suicide attempts by self-poisoning in the United States among 10–25 year olds from 2000 to 2018: substances used, temporal changes and demographics – Journal of Clinical Toxicology (free)
10 – Oral Paracetamol Versus Combination Oral Analgesics for Acute Musculoskeletal Injuries – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary: RCT – APAP Only vs APAP-Ibuprofen-Codeine Combo – Journal Feed (free)
Practice-Changing: Tranexamic Acid Reduces the Risk of Head Injury-related Death in Patients with Mild-to-moderate Head Injury
15 Oct, 2019 | 10:56h | UTCCommentaries: CRASH-3: a win for patients with traumatic brain injury – The Lancet (free) AND Global trial is first clear evidence that a widely available drug reduces head injury deaths – London School of Hygiene & Tropical Medicine (free) AND PulmCrit- Tranexamic acid for traumatic brain injury (CRASH3) (free) AND CRASH-3! – Emergency Medicine Literature of Note (free) AND Head injuries: Cheap drug ‘could save thousands of lives a year’ – BBC (free) AND Common drug could prevent thousands of head injury deaths – The Guardian (free)
Related: Evidence Review: Tranexamic Acid (TXA) for Everything that Bleeds? (free resources on the subject)
[Abstract Only] Meta-Analysis: Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia
15 Oct, 2019 | 10:35h | UTCComparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-pharmacologic treatments may be more effective for psychiatric symptoms of dementia – St. Michael’s Hospital (free) AND To ease dementia agitation, drugs may not be best option – Reuters (free)
[Abstract Only] Randomized Trial: Similar Outcomes with Conservative Oxygen Therapy vs. Usual Oxygen Therapy During Mechanical Ventilation
15 Oct, 2019 | 10:55h | UTCConservative Oxygen Therapy during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: No clear benefit from conservative oxygen in mechanical ventilation – CHEST Physician (free) AND Trial: No Need for Intensive Oxygen in the ICU – MedPage Today (free registration required)
Updated NICE Guideline: Diabetic Foot Problems
15 Oct, 2019 | 10:47h | UTCRelated: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine (free) AND Diabetic foot – The BMJ (free) AND Diagnosis and Management of Diabetic Foot Complications – American Diabetes Association (free) AND Prevention, assessment, diagnosis and management of diabetic foot based on clinical practice guidelines: A systematic review – Medicine (free)
[Abstract Only] Randomized Trial: DOAC Not as Good as Vitamin K Antagonist for Anticoagulation in Antiphospholipid Syndrome
15 Oct, 2019 | 10:32h | UTCRivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Rivaroxaban Not Noninferior to VKAs for Antiphospholipid Antibody Syndrome – NEJM Journal Watch (free) AND DOAC Disappoints in Thrombotic Autoimmune Disorder – MedPage Today (free registration required)
Study: Youth Suicide Attempts Often Involve Over-the-counter Painkillers
15 Oct, 2019 | 10:16h | UTCYouth suicide attempts often involve over-the-counter painkillers – Reuters (free)
Original Study: Suicide attempts by self-poisoning in the United States among 10–25 year olds from 2000 to 2018: substances used, temporal changes and demographics – Journal of Clinical Toxicology (free)
Randomized Trial: Wirelessly Observed Therapy vs. Directly Observed Therapy to Confirm Tuberculosis Treatment Adherence
15 Oct, 2019 | 10:31h | UTCCommentary: Ingestible sensor allows patients to be independent but still supported during TB treatment – Specialists in Global Health (free)
Podcast: Osteoarthritis Master Class
15 Oct, 2019 | 10:22h | UTCSee also: Episodes List
Review: Management of Itch in the Elderly
15 Oct, 2019 | 10:17h | UTCManagement of Itch in the Elderly: A Review – Dermatology and Therapy (free)
[Abstract Only] Randomized Trial: Oral Paracetamol Versus Combination Oral Analgesics for Acute Musculoskeletal Injuries
15 Oct, 2019 | 10:14h | UTCOral Paracetamol Versus Combination Oral Analgesics for Acute Musculoskeletal Injuries – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary: RCT – APAP Only vs APAP-Ibuprofen-Codeine Combo – Journal Feed (free)
Guidelines for the Surgical Management of Enteral Stomas in Adults
15 Oct, 2019 | 10:12h | UTC
Special Issue: Neonatal ECMO in 2019
15 Oct, 2019 | 10:11h | UTCHomepage: Neonatal ECMO in 2019: Where Are We Now? Where Next? – Frontiers in Pediatrics (free articles)
– Anticoagulation in Neonatal ECMO: An Enigma Despite a Lot of Effort!
– Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge
– Neonatal Cardiac ECMO in 2019 and Beyond
– Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia
Systematic Review: Evaluation of E-learning for Medical Education in Low- and Middle-income Countries
15 Oct, 2019 | 10:13h | UTC
Position Statement: Treatment of Hyperglycemia in Patients with Type 2 Diabetes and Impaired Renal Function
15 Oct, 2019 | 08:38h | UTCRelated: New ADA 2020 Guidelines for the Management of Diabetes (free)
A Fairer Way Forward for AI in Health Care
15 Oct, 2019 | 08:45h | UTCA fairer way forward for AI in health care – Nature (free)
[Abstract Only] Randomized Trial: Treatments for Multiple Sclerosis Compared
15 Oct, 2019 | 08:35h | UTCSafety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary: Measure From RADIANCE Data Suggests Ozanimod More Effective in Slowing MS Disease Activity – AJMC (free)
Source: EvidenceAlerts
[Abstract Only] Randomized Trial: Anti-CD19 Monoclonal Antibody Tested for the Treatment of Neuromyelitis Optica Spectrum Disorder
15 Oct, 2019 | 08:29h | UTCInebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Anti-CD19 MAb Trial Halted Early for Benefit in NMO – Medscape (free registration required)
Cardiovascular Risk in Fatty Liver Disease: The Liver-Heart Axis—Literature Review
15 Oct, 2019 | 08:23h | UTC
Extrahepatic Complications of Non-alcoholic Fatty Liver Disease
15 Oct, 2019 | 08:14h | UTC
Study: Non-alcoholic Fatty Liver Disease and Risk of Incident Acute Myocardial Infarction and Stroke
15 Oct, 2019 | 08:08h | UTC