Daily Archives: August 6, 2019
Tue August 6 – 10 Stories of The Day!
6 Aug, 2019 | 08:17h | UTC
2 – Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)
Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)
“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”
3 – Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)
“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.
4 – #164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)
Commentaries: Expert reaction to study reporting ‘spin’ in abstracts of psychiatry and psychology journals – Science Media Centre (free) AND ‘Spin’ found in over half of clinical trial abstracts published in top psychiatry journals – The British Medical Journal (free)
Related: Systematic Review: Spin in Published Cardiovascular Randomized Trials with Statistically Nonsignificant Primary Outcomes (free study and editorial) AND ‘Spin’ in published biomedical literature: A methodological systematic review – PLOS Biology (free)
6 – Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Commentaries: Global burden of childhood cancer: growing, but controllable – The Lancet Oncology (free) AND Globally, more than 11 million years of healthy life lost due to childhood cancer in 2017 – The Lancet (free)
Summary: Financial conflicts of interests and results, conclusions, and quality of systematic reviews – Cochrane Library (free)
10 – Renin-Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: RAS Inhibition After TAVR Gains More Support, but RCT Still Needed – TCTMD (free) AND Renin-angiotensin system inhibition following transcatheter aortic valve replacement linked with lower cardiac mortality – 2 Minute Medicine (free)
Cohort Study: Perioperative Management of Patients with Atrial Fibrillation Receiving a Direct Oral Anticoagulant
6 Aug, 2019 | 08:10h | UTCPerioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)
Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)
“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”
Related Commentary on Twitter
PAUSE is the largest trial to date that addresses perioperative DOAC timing and demonstrates safe management with the ability to influence guidelines https://t.co/WDM3yWt9nA
— JAMA Internal Medicine (@JAMAInternalMed) August 5, 2019
AGA Guideline on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults
6 Aug, 2019 | 08:15h | UTC
Potential Savings from Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers
6 Aug, 2019 | 08:06h | UTCPotential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)
“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.
Study: Evaluation of “Spin” in Abstracts of Papers in Psychiatry and Psychology Journals
6 Aug, 2019 | 08:02h | UTCCommentaries: Expert reaction to study reporting ‘spin’ in abstracts of psychiatry and psychology journals – Science Media Centre (free) AND ‘Spin’ found in over half of clinical trial abstracts published in top psychiatry journals – The British Medical Journal (free)
Related: Systematic Review: Spin in Published Cardiovascular Randomized Trials with Statistically Nonsignificant Primary Outcomes (free study and editorial) AND ‘Spin’ in published biomedical literature: A methodological systematic review – PLOS Biology (free)
Podcast: Stroke and TIA Deconstructed
6 Aug, 2019 | 08:04h | UTC#164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)
The Global Burden of Childhood and Adolescent Cancer
6 Aug, 2019 | 07:57h | UTCCommentaries: Global burden of childhood cancer: growing, but controllable – The Lancet Oncology (free) AND Globally, more than 11 million years of healthy life lost due to childhood cancer in 2017 – The Lancet (free)
Related Commentary on Twitter
Childhood cancer is the 6th leading cause of cancer burden globally with more than 11.5 million disability-adjusted life-years in 2017. Read our latest #GBDstudy online: https://t.co/FrUm2xPf4h pic.twitter.com/3cJrn5RtTw
— IHME at UW (@IHME_UW) July 30, 2019
Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
6 Aug, 2019 | 07:58h | UTC
Alex Nowbar’s journal review—5 August 2019
6 Aug, 2019 | 08:00h | UTCAlex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Financial Conflicts of Interest in Systematic Reviews: Associations with Results, Conclusions, and Methodological Quality
6 Aug, 2019 | 07:55h | UTCSummary: Financial conflicts of interests and results, conclusions, and quality of systematic reviews – Cochrane Library (free)
[Abstract Only] Observational Study: Renin-Angiotensin System Inhibition May Improve Prognosis Following Transcatheter Aortic Valve Replacement
6 Aug, 2019 | 07:53h | UTCRenin-Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: RAS Inhibition After TAVR Gains More Support, but RCT Still Needed – TCTMD (free) AND Renin-angiotensin system inhibition following transcatheter aortic valve replacement linked with lower cardiac mortality – 2 Minute Medicine (free)
Related Commentary on Twitter
Renin-angiotensin system inhibitors may improve outcomes after #TAVR. View data collected from over 2,500 patients with severe #vhdAS in #JACC. https://t.co/htFLXsS2l2 pic.twitter.com/aOIzwdETX2
— JACC Journals (@JACCJournals) August 5, 2019