Daily Archives: October 26, 2018

“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)

Cohort Study: Angiotensin Converting Enzyme Inhibitors and Risk of Lung Cancer

26 Oct, 2018 | 02:43h | UTC

Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study – The BMJ (free)

Editorial: Angiotensin converting enzyme inhibitors and lung cancer (free)

Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)

Meta-Analysis: Efficacy, Effectiveness, and Safety of Herpes Zoster Vaccines

26 Oct, 2018 | 02:42h | UTC

Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis – The BMJ (free)

“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”

Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS

26 Oct, 2018 | 02:39h | UTC

Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past (free)

“Among patients in the ICU receiving invasive ventilation, a strategy with low tidal volume was not more effective than a strategy using intermediate tidal volume.”

Prophylactic Hypothermia Questioned After Severe Traumatic Brain Injury

26 Oct, 2018 | 02:40h | UTC

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hypothermia After Traumatic Brain Injury (free)

Commentary: Hypothermia for Severe TBI Called into Question – NEJM Journal Watch (free)

Study: Association of Weather with Incidence of Myocardial Infarction

26 Oct, 2018 | 02:38h | UTC

Association of Weather with Day-to-Day Incidence of Myocardial Infarction: A SWEDEHEART Nationwide Observational Study – JAMA Cardiology (free)

Commentaries: Your risk of a heart attack could increase as it gets colder, study says – CNN (free) AND Cold, cloudy weather ‘could increase your risk of having heart attack’ – The Guardian (free)

Observational Study: Blood Pressure Levels and Outcomes in Patients With Diabetes Mellitus and Coronary Artery Disease

26 Oct, 2018 | 02:36h | UTC

Average Clinician‐Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial – Journal of the American Heart Association (free)

Editorial: The Ongoing Saga of Optimal Blood Pressure Level in Patients With Diabetes Mellitus and Coronary Artery Disease (free)

“A U‐shaped relationship between cardiovascular outcomes and BPs was observed.”

Observational Study: Blood Pressure Levels and Outcomes in Patients With Peripheral Artery Disease

26 Oct, 2018 | 02:33h | UTC

Association of Blood Pressure Measurements With Peripheral Artery Disease Events: Reanalysis of the ALLHAT Data – Circulation (free)

Editorial: New Curveball for Hypertension Guidelines? Blood Pressure Targets in Peripheral Artery Disease (free)

“we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP.”

Study: Score Predicts 90-Day Risk of Readmission After Acute Myocardial Infarction

26 Oct, 2018 | 02:32h | UTC

Clinical Model to Predict 90-Day Risk of Readmission After Acute Myocardial Infarction: A Report From the National Cardiovascular Data Registry ACTION Registry – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Score predicts 90-day readmission risk after myocardial infarction – ACP Hospitalist (free) AND Novel risk predictor identifies likelihood of readmission after AMI – Cardiovascular Business (free)

Pulmonary Embolism: Contemporary Medical Management and Future Perspectives

26 Oct, 2018 | 02:32h | UTC

Review: Pulmonary Embolism: Contemporary Medical Management and Future Perspectives – Annals of Vascular Disease (free PDF)

Meta-Analysis: Self-Monitoring of Blood Glucose Provides no Important Benefit for Most People with Type 2 Diabetes

26 Oct, 2018 | 02:30h | UTC

Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes – NIHR Signal (free)

Original Article: Self-monitoring blood glucose improves glycemic control in type 2 diabetes without intensive treatment: A systematic review and meta-analysis – Diabetes Research and Clinical Practice (link to abstract – $ for full-text)

Guideline: Male Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia

26 Oct, 2018 | 02:31h | UTC

Canadian Urological Association guideline on male lower urinary tract symptoms/benign prostatic hyperplasia (MLUTS/BPH): 2018 update – Canadian Urological Association Journal (free)

Related Guideline: Surgical Management of Lower Urinary Tract Symptoms attributed to BPH (free guideline and commentary)

ACTIVE: A Technical Package for Increasing Physical Activity

26 Oct, 2018 | 02:29h | UTC

ACTIVE: A technical package for increasing physical activity – World Health Organization (free PDF)

News Release: WHO launches ACTIVE: a toolkit for countries to increase physical activity and reduce noncommunicable diseases (free)

Editorials: Challenges and Opportunities for Studying Routine Screening for Abuse (free) AND Addressing Intimate Partner Violence and Abuse of Older or Vulnerable Adults in the Health Care Setting—Beyond Screening (free)

Perspective: The Problem with Probiotics

26 Oct, 2018 | 02:08h | UTC

The Problem With Probiotics – The New York Times (free)

Related: Probiotic Safety—No Guarantees (free perspective)

“There are potential harms as well as benefits, and a lot of wishful thinking and imprecision in the marketing of products containing them.”

Guideline: Oxygen Therapy for Acutely Ill Medical Patients

Guideline: Antiplatelet Therapy in Patients Undergoing Elective Invasive Procedures

Review: The Global Burden of Multiple Chronic Conditions

The Skeptic: What Precision Medicine Revolution?

Perspective: The Troubling Epidemic of Unnecessary C-sections Around the World, Explained

Review: Similarities and Differences Between Biliary Sludge and Microlithiasis

Review: Pacemaker‐Mediated Arrhythmias

Randomized Trial: Low-Dose Imipramine for Refractory Functional Dyspepsia

Randomized Trial: Proton-Pump Inhibitors Prophylaxis of Little Benefit in the ICU