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Daily Archives: October 5, 2017

Thu, October 5 – 10 Stories of The Day!

5 Oct, 2017 | 02:05h | UTC

 

1 – Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine — Preliminary Report – New England Journal of Medicine (free)

Commentaries: First human trial of DNA-based Zika vaccine shows promise – CIDRAP (free) AND DNA-based Zika vaccine candidate found safe and effective at inducing immune response – University of Pennsylvania School of Medicine, via EurekAlert (free) AND Zika vaccine shows promise in early human trial – Reuters (free)

 

2 – Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

“All too often non-inferiority clinical trials are a means of asserting false equivalence” (RT @EricTopol see Tweet)

 

3 – Guidelines for the Management of Congenital Heart Diseases in Childhood and Adolescence – The German Society of Paediatric Cardiology (free PDF)

 

4 – New Choosing Wisely Recommendations

Choosing Wisely US: Five Things Physicians and Patients Should Question: American Academy of Pediatrics – Section on Endocrinology (free) AND Commentary: Choosing Wisely: 5 Pediatric Endocrinology Tests to Avoid – Physician’s First Watch (free)

Choosing Wisely Canada: Nine Things Nurse Practitioners and Patients Should Question – Nurse Practitioner Association of Canada (free)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

5 – Outcomes In Two Massachusetts Hospital Systems Give Reason For Optimism About Communication-And-Resolution Programs – Health Affairs (link to abstract – $ for full-text)

Commentaries: After medical error, apology goes a long way – Stanford University Medical Center, via ScienceDaily (free) AND Conflict Resolution Program: ‘Cause for Optimism’ – MedPage Today (free registration required)

Explaining and apologizing to patients after a medical error does not increase lawsuits, large US study finds” (RT @bmj_latest see Tweet)

 

6 – Exercise and the Prevention of Depression: Results of the HUNT Cohort Study – American Journal o Psychiatry (free)

Commentary: Just One Hour of Exercise a Week May Help Prevent Depression – TIME Magazine (free) AND One hour of exercise a week can prevent depression – EurekAlert (free) AND What’s the ultimate way to defy depression, disease and early death? Exercise – The Guardian (free)

 

7 – The high price of anticancer drugs: origins, implications, barriers, solutions – Nature Reviews: Clinical Oncology (free PDF)

Related: Cancer drugs are getting better and dearer – The Economist (a few articles per month are free) Financial toxicity: 1 in 3 cancer patients have to turn to friends or family to pay for care – STAT News (free) AND Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR (free) AND Financial Toxicity and Cancer Treatment (PDQ®) – National Institute of Cancer (free) AND Financial Toxicity: Cancer Supportive Care Professionals Consider the Side Effects of Soaring Costs – ASCO Post (free)

 

8 – Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentaries: Summary of studies on sleep deprivation didn’t caution that depression benefits are short lived – HealthNewsReview (free) AND Sleep Deprivation May Treat Depression. But Would It Ever Be Prescribed? – Forbes (free) AND Sleep Deprivation a Rapid, Effective Depression Treatment – Medscape (free registration required) AND Sleep deprivation rapidly reduces depression symptoms in nearly half of depressed patients – News Medical (free)

 

9 – Respiratory support in patients with acute respiratory distress syndrome: an expert opinion – Critical Care (free)

Related article published recently: Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free) AND Editorial: Lung Recruitment and Titrated PEEP in Moderate to Severe ARDS: Is the Door Closing on the Open Lung? (free)

 

10 – Association Between Use of Antithrombotic Medication and Hematuria-Related Complications – JAMA (link to abstract – $ for full-text)

Commentaries: Antithrombotics Associated with Gross Hematuria – Physician’s First Watch (free) AND Haematuria more common in people taking antithrombotics – OnMedica (free)

 


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